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Clin Gastroenterology H: Inconsistencies between clinical manifestations in patients with mild moderate ulcerative colitis and inflammation of mucosa.

 Last Update: 2020-08-11
 Source: Internet
 Author: User

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The relationship between rectal bleeding and increased number of stools and endoscopy examination is poorly known for patients with mild to moderate ulcerative colitis (UC) in context and targets.
study to assess the relationship between rectal bleeding or stool counts in this population and endoscopic remission.
method researchers analyzed 817 mild to moderate UC adults treated with mesalaquinin for rectal bleeding at weeks 0, 8 and 38, respectively, and used Spearman's rank correlation coefficients to quantify the association between rectal bleeding and changes in fecal frequency and changes in the Mayo score (MES) after treatment.
patients with a MES score of 0 had a rectal haemorrhage score of 1 or higher in week 8 of 7/82 patients (9 percent), and 40/82 patients (49 percent) had a fecal frequency score of 1 or higher.
at week 38, 6/167 patients (4%) had a rectal hemorrhage score of 1 or higher, while 63/167 patients (38%) had a fecal frequency score of 1 or higher.
in patients with a MES of 0 or 1, 50/310 (16%) had a rectal hemorrhage score of 1 or higher, while 162/310 patients (52%) had a fecal frequency score of 1 or higher in week 8.
at week 38, 18/363 patients (5%) had a rectal hemorrhage score of 1 or higher, while 141/363 patients (39%) had a fecal frequency score of 1 or higher.
the spearman grade correlation coefficient with MES changes with the frequency of rectal bleeding and feces at week 8 of
was 0.39 (95% CI, 0).
32-0.45) and 0.34 (95% CI, 0.27-0.40).
39/389 patients with reduced MES (10%) had no change or deterioration of rectal bleeding in the 8th week, while 81/389 patients (21%) had no change or increase dysenteric frequency.
ConclusionS in this study found no correlation between rectal symptoms and endoscopy, and that the number of bowel stools increased in many patients during the remission period, suggesting that the number of bowel blems and bowel stools was not a sensitive marker of disease activity in patients with mild to moderate UC.
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