Clin Gastroenterology H: Increased esophageal symptoms in obese patients due to increased esophageal acid exposure rather than movement disorders

Background and objectiveesophageal motor disorder (EMD) and pathological reflux are commonly found in obese people, but it is not clear how obesity causes these symptomsThe purpose of this study was to analyze the relationship between symptom burden, EMD, acid exposure time (AET), symptom association probability, and body mass index (BMI)MethodsThis study is a retrospective study conducted at a three-level referral center for a continuous period of 1089 patients who received high-resolution pressure measurements, of which 426 patients were also subjected to antiacid monitoring to inhibit acid suppressionThe symptom burden was assessed through questionnaires to determine the intensity of the main symptoms at that time and the overall severity of the symptoms, esophagus examination; We compared the proportion of patients in the BMI category with the burden of EMD and reflux abnormalities and associated them with symptom burdensresults433 patients (39.8%) met EMD standardsThe incidence of EMD in patients with low BMI (less than 25.9 percent weight; 14.1 percent of the normal population; 13.9 percent overweight; 9.8 percent ;P in obese populations , .037), but the incidence of EMD in obese patients was lower (although the symptom burden was higher than in non-obese patients (DSI, 10.5 to 0.3 vs 9.7?0.2; P - .03 and GSS, 6.5 x 1 vs 5.9 x 1; POf the 426 patients subjected to reflux monitoring, the proportion of total AET (P s .02) and upright AET (P .001) increased in the BMI category, with a strong trend of reclining AET (P s 0.06), compared with DSI and GSS (increased combination P .001 for each comparison)BMI is associated with symptom burden, higher AET and positive symptom salike (P 0.01 per analysis)Conclusionsthe increased symptom burden ofobese individuals is associated with the burden of esophageal acid, but not with motor disorders