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We know that acute alcoholic hepatitis (AAH) is one of the leading diseases leading to liver-related deaths.
At present, the diagnosis of alcoholic liver disease or determine the degree of cell death of good blood biomarkers are still relatively rare, or even that there is no specific biological indicators can predict the occurrence and prognosis of such diseases, has become one of the hot issues in the academic community.
recently, researchers found that keratin 18 (KRT18, also known as K18) found in epithelial cells is released from liver cells when they die, so whether K18 levels are a good predictor of liver cell death is a problem this study wants to address.
a large trial at four medical centers analyzed clinical data from 173 participants.
participants with AAH were classified as severe (n s 57, end-stage liver disease model (MELD) scored higher than 20) or moderate (n s 27, MELD score from 12 to 19).
38 participants had mild (n - 28) or no liver damage (n s 10), 34 participants had non-alcoholic fatty hepatitis, and 17 participants were included in the health (control group).
testing of K18 levels, the researchers used ELISA and APOPTOSENSE kits to quantify the serum levels of K18.
results showed that serum alanine amino metastase (ALT), levels of tinonine amino metastase (AST) and AST:ALT ratio were not related to MELD scores.
levels of serum ALT were higher in patients with alcohol abuse disorder than in patients with severe AAH.
with the worsening of liver disease, levels of K18M65 and K18M30 increased statistically, as did necrotization.
the proportion of K18M65:ALT in the serum of AAH patients increased compared to the control group.
who were identified with serum K18 died within 90 days with greater accuracy than other biomarkers commonly used.
: The worsening of liver disease, the higher the levels of K18M65 and K18M30, the stronger the association between serum keratin 18 levels and liver cell deaths and the severity of liver disease compared to other biomarkers (AST, ALT and AST:ALT).
K18M65: The M30 ratio can be used as a marker of hepatocellular death mechanism, K18M65: ALT ratio can be used to distinguish between AAH patients and non-alcoholic fatty hepatitis patients.
serum K18 levels can be used to identify patients with severe AAH who are at serious risk of death.
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