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Microcosmic colitis is a chronic inflammatory bowel disease in the colon, which manifests it as chronic diarrhea.
is one of the most common causes of watery diarrhea in the elderly.
in Sweden, one in 115 women and one in 286 men is diagnosed with microcosmic colitis.
earlier studies showed that more than 50 percent of patients needed steroid treatment, and that a large proportion experienced frequent relapses, leading to a significant decline in quality of life.
the risk of hospitalization was low, in one study as many as 10 per cent of patients were hospitalized for severe diarrhoea.
As the incidence of diseases increases, especially among the more infirm elderly population, such diseases will have a significant impact on public health, the study aims to explore the full cause and mortality rates of microcosmic colitis patients.
researchers conducted a national cohort study analysis of all cases of microcosmic colitis (n - 14333) diagnosed in Sweden between 1990 and 2017.
and matched each case of microcosmic colitis to five healthy populations.
mortality data are determined by the Swedish Coroner's Register.
to use the Cox Scale Risk Model to estimate the adjusted risk ratio (aHRs) and 95% CI.
as of December 2017, researchers had identified a total of 3,014 deaths (27.4 / 1000 years) in microcosmic colitis patients and 12,534 deaths (23.3 / 1000 years) in a healthy population.
this equates to a 10-year absolute risk variance of 3.4 per cent (95 per cent CI, 2.1 per cent - 4.6 per cent).
, however, further adjustments to the combined burden model reduced the relative risk of death in patients with microcosmic colitis (aHR, 0.98; 95% CI, 0.94-1.02).
in death analysis for specific causes, microcosmic colitis was associated with gastrointestinal deaths (aHR, 1.68; 95% CI, 1.38-2.05) and infection-related deaths (aHR, 1.42; 95% CI, 1.11-1.83) was associated, but not cancer-related deaths (aHR, 0.83; 95% CI, 0.76-0.91) or cardiovascular-related deaths (aHR, 1.02; 95% CI, 0.96-1.10).
study, we found an increased risk of death in patients with microcosmic colitis.
, however, appears to be related to an increase in the burden of merging disorders in the population.
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