Clin Gastroenterology H: Reduced physical labor capacity and iron utilization in adolescents with non-alcoholic fatty liver disease

Background and targetnon-alcoholic fatty liverdisease (NAFLD) is common and is associated with obesity and insulin resistanceThe loss of iron metabolism in obese individuals is associated with physical inactivityThe study was designed to explore whether iron bioavailability in NAFLD patients decreased and helped reduce heart and lung adaptabilitymethodsresearchers collected information about weight, maximum physical activity (PWC), ultrasound-determined liver fat degeneration, iron index, and hematopoietic and metabolic parameters from 390 female and 458 male participants in raine's studyresults14 per cent of participants in thequeue had NflDCompared to adolescents without NAFLD, the PWC of adolescents with NAFLD decreased significantly (reduced by 0.17 W / kg, P - .0003)The bioavailability of iron (by mean red blood cell volume (MCV), average red blood cell hemoglobin (MCH), trans-ferritin saturation and serum iron level assessment) was negatively correlated with NAFLD adolescent BMI (P .01), and non-NAFLD-free adolescents (P s .30)MCV and MCH are associated with PWC (MCV, female participant P s .002, male participant P s .0003; MCH, female P is P s 0.004, male is P s 0.01), and is not related to NAFLD identityThe lower PWC for adolescents with NAFLD was associated with lower ferritin saturation (0.012 W/kg per unit, P .007) and adolescents without NAFLD were not associated (decrease of 0.001 W/ kg, P s .40)conclusions
this study found that NAFLD is associated with reduced cardiopulmonary health and is independent of BMI The relationship between the saturation of ferritin in adolescents with NAFLD and PWC suggests that functional iron deficiency may lead to reduced vistosensitivity to cardiopulmonary function