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Background and target 5-aminosic slyacid (5-ASA) suptin suptinuate is not effective in treating refractory ulcerctor rectal itis (UP) and generally requires further treatment with immunomodulators or biotherapy gradually.
local treatment of tacmos is effective and safe for patients with refractive UP, this study aims to compare the efficacy of tasterise compared to hormones.
method researchers conducted a randomized controlled double-blind study.
randomly divided 85 patients with refractory UP patients (65% female) into two groups, one group giving tamoxemin once a day (2 mg; n s 43) or the other group to perclomin (3 mg; n s 42) treatment for 4 weeks. the main result of
is a clinical response (Mayo score decreases by 3 or more).
secondary outcomes include clinical remission, endoscopy and remission, adverse events, and quality of life.
the proportion of patients with clinical response in the tamoxose group was 63%, the perchloromipine group was 59% (P - 0.812), and the proportion of clinical lysanosis patients was 46% and 38% respectively (P - 638).
the proportion of patients with endoscopy in the tacrosandos group and perchloromione group was 68% and 60% respectively (P -636);
the median of the questionnaire for inflammatory bowel disease in the tacros group increased to 18.0 and the perchlormione group to 20.5 (P .395). There was no significant difference in the incidence of adverse events between the two groups
.
Conclusion Sandidos compared the efficacy of his kermosis and perchloromipine suppositories in patients with 5-ASA refractive UP in multiple dimensions.
proved that both tamoxis and perchloromipine suppositories are effective treatment options for 5-ASA refractive ulcerative colitis.
.