Clin Gastroenterology H: Testosterone levels are associated with the development of hepatitis and fibrosis in women with NAFLD

Non-alcoholic fatty liver disease (NAFLD) affects approximately 20-35% of the world’s population.
With the acceleration of global industrialization and changes in diet, the epidemiological manifestations of NAFLD are also changing, with more and more women and young people People under the age of 40 are at a high risk of increasing NAFLD.
Compared with men, female patients are more affected by non-alcoholic liver disease and are more likely to develop liver cirrhosis and end-stage liver cancer
.

Non-alcoholic fatty liver disease (NAFLD) affects approximately 20-35% of the world’s population.
With the acceleration of global industrialization and changes in diet, the epidemiological manifestations of NAFLD are also changing, with more and more women and young people Begin to be threatened by NAFLD.
People under 40 years old are the population with a high incidence of NAFLD growth, non-alcoholic fatty liver

 

Testosterone is traditionally regarded as a "male" sex hormone, which plays an important role in the body.
Testosterone hormone has obvious sex type 2 effects on metabolic diseases.
Among them, male testosterone deficiency can lead to diabetes and visceral obesity, and higher The level of testosterone in women is associated with an increased risk of NAFLD disease in women
.

Therefore, this study aims to confirm the correlation between testosterone levels and the severity of the disease in women with NAFLD

diabetes

 

 

The researchers collected the clinical data of 207 premenopausal women with NAFLD confirmed by biopsy, and determined the relationship between free testosterone (free T) and non-alcoholic steatohepatitis (NASH) in female patients
.

Taking into account the decline of testosterone levels with age and the correlation between age and NASH, the interaction test between age and free T was carried out

 

The results of the study showed that the median age of the female patients included in this study was 35 years old (interquartile range, 29-41 years old); 73% were white, 25% were Hispanic; 32% had diabetes, and 93% had diabetes.
There is abdominal obesity, and 95% suffer from dyslipidemia
.

69% had NASH, 67% had liver fibrosis, and 15% had advanced fibrosis

Figure: The effect of different testosterone levels on liver fiber

This study confirmed that in young women with NAFLD, higher testosterone levels double the risk of NASH and NASH fibrosis, and increase the risk of abdominal obesity.
Testosterone may be an early risk factor for the progression of NASH in young women
.

      This study confirmed that in young women with NAFLD, higher testosterone levels double the risk of NASH and NASH fibrosis, and increase the risk of abdominal obesity.
Testosterone may be an early risk factor for the progression of NASH in young women
.

 

 

Original source:

Monika A.

Testosterone is Associated With Nonalcoholic Steatohepatitis and Fibrosis in Premenopausal Women With NAFLD.
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