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Background and targetserumlow levels of vitamin Dare associated with Crohn's disease (CD)However, it is not clear whether low vitamin D levels caused CDs or CDs to reduce serum vitamin D levelsmethod
researchers matched the CD (n s 240) of U.Smilitary personnel and randomly selected individuals without CDs (n s 240) by age, gender, race, military sector, and geographic location25-hydroxy vitamin D was measured in the first 2 years and3 months (1 year) before the diagnosis and 21 months to 3 months to 3 months before diagnosis (0)We genetically typed polymorphisms associated with VDR and GC vitamin DUse conditional regression, including smoking, seasoning, enlistment status and deployment adjustments, to estimate the relative probability of CD based on vitamin D levels and the interaction between genetic factors and vitamin D levelsresultspre-diagnosis levels of vitamin D were not related to CDs in 2 years ago (P .65) or 1 year ago (P .84)However, in the samples after diagnosis, the researchers found a negative correlation between cDs and the highest triple digits of vitamin D (P -0.01; advantage ratio 0.51; 95% CI was 0.30-0.86) No interaction between vitamin D levels and VDR or GC polymorphismwas was detected, and the researchers observed a link between VDR Taq1 polymorphism and CD (no dependence on vitamin D) (P conclusions
found no association between CD and vitamin D levels up to eight years before diagnosis in this study However, post-diagnosis vitamin D levels were observed to be negatively correlated with CD These findings suggest that low vitamin D does not promote the development of CD, which instead causes low vitamin D