Clin Infect Dis: Researchers at the University of California, San Francisco found antibody affinity index characteristics in patients with new crowns.

Dr. Dr. Yiqi Ruben Luo and Dr. Kara Lynch and others have developed a new method for testing the affinity of IgG antibodies in SARS-COV-2 using unmarked immunoanalysing techniques.
the study of SARS-CoV-2 antibodies has become a priority in the study of new coronary immunity.
Most patients with symptoms can detect SARS-CoV-2 antibodies within two weeks of the on-on-the-oncology of symptoms, and serum antibody concentrations in severe and non-severe patients begin to show statistically significant differences after serum conversion (i.e., the point at which antibodies are detected in the serum).
addition to concentration, there are other important indicators for measuring antibodies, including affinity, meso-ability, sub-type, etc.
Generally speaking, high-concentration and high-affinity antibodies have strong viral neutrality and are protective antibodies, but some low-concentration and low-affinity antibodies can also promote disease progression.
, a scientist at the University of California, San Francisco (UCSF). Yiqi Ruben Luo and Dr. Kara Lynch and others have developed a new method for testing the affinity of IgG antibodies in SARS-COV-2 using unmarked immunoanalysing techniques.
the study has been received by Clinical Medical Diseases.
researchers used unmarked immunoanalysis to develop a new detection method to test the affinity of THES-COV-2's IgG antibody, using this method to study 168 serum samples from 90 patients from the initial stages of diagnosis to the recovery period.
results showed a strong correlation between IgG affinity and the number of days after onset (Figure A), and for individual patients, IgG affinity increased over time (Figure B), and IgG affinity from serum samples from ICU patients was higher than in non-ICU patients (Figure C) one month after onset.
the study of SARS-CoV-2 antibodies has become a priority in the study of new coronary immunity.
Most patients with symptoms can detect SARS-CoV-2 antibodies within two weeks of the on-on-the-oncology of symptoms, and serum antibody concentrations in severe and non-severe patients begin to show statistically significant differences after serum conversion (i.e., the point at which antibodies are detected in the serum).
addition to concentration, there are other important indicators for measuring antibodies, including affinity, meso-ability, sub-type, etc.
Generally speaking, high-concentration and high-affinity antibodies have strong viral neutrality and are protective antibodies, but some low-concentration and low-affinity antibodies can also promote disease progression.
, a scientist at the University of California, San Francisco (UCSF). Yiqi Ruben Luo and Dr. Kara Lynch and others have developed a new method for testing the affinity of IgG antibodies in SARS-COV-2 using unmarked immunoanalysing techniques.
the study has been received by Clinical Medical Diseases.
researchers used unmarked immunoanalysis to develop a new detection method to test the affinity of THES-COV-2's IgG antibody, using this method to study 168 serum samples from 90 patients from the initial stages of diagnosis to the recovery period.
results showed a strong correlation between IgG affinity and the number of days after onset (Figure A), and for individual patients, IgG affinity increased over time (Figure B), and IgG affinity from serum samples from ICU patients was higher than in non-ICU patients (Figure C) one month after onset.
antibody affinity detection method used in this article is based on TFI (Thin-Film Interferometry) unmarked immunoanalytation techniques to directly observe the formation and deconsociation of immune complexes over time.
the probe used by the company is coated with RBD recombination protein (purchased from Yiju Shenzhou).
serum samples are diluted 10 times in the buffer.
antibody affinity measurement steps mainly include: the probe into the buffer for standard line measurement, and then on the probe to form RBD-antibody immune complex, and then rinse with buffer, and finally with the second anti (goat antibody) to form RBD-antibody-ii-immune complex.
this is the first study of the antibody affinity index and its trends over time in new coronary patients.
recent study from the UK showed that antibody concentration and liation in new crown patients decreased over time, and the team observed the same phenomenon (the results were not published).
current studies have not found that antibody affinity decreases over time, it is inferred that a decrease in antibody concentration may be a major factor in the decrease in antibody's melium.
in the pandemic of the new crown epidemic, research in the field of life sciences has made breakthroughs, and the understanding of all aspects of the virus is also deepening.
As a well-known company in the field of life science research, Yiqiu Shenzhou, on the occasion of National Day and Mid-Autumn Festival, will also send you a sincere spirit and economic double trench salute when the motherland is wishing to flourish.
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