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In laboratory studies, vitamin E can affect the immune system.
dozens of animal experiments have found that vitamin E is protective of infections caused by viruses and bacteria.
previously, vitamin E supplementation has been found to have significant heterogeneous effects on human pneumonia.
study to explore how vitamin E affects pneumonia risk depends on age.
conducted a secondary analysis of the 1985-1993 study of alpha-procopter and beta-carotene cancer prevention in Finland.
participants were male smokers aged 50 to 69 and male smokers who started smoking at the age of 21 (N-7 469).
intervention is vitamin E 50 mg/d, lasting 5 to 8 years. the results of
were the incidence of hospital treatment and community-acquired pneumonia of all ages at the time of follow-up.
results, vitamin E supplementation reduced the incidence of pneumonia by 69% (95% confidence interval (CI) 43-83%; 57 cases of pneumonia) among the 2,216 participants who smoked 5-19 cigarettes per day at baseline and exercised at leisure.
in this subgroup, vitamin E prevented 12.9 percent of participants from contracting pneumonia before the age of 74.
the incidence of pneumonia among the 5,253 participants who smoked 20 cigarettes or did not exercise at baseline decreased by 14% (95% CI:-38% to 21%; 139 cases).
one-third of the participants quit smoking for a while, and 27 of them had pneumonia.
a 72 percent reduction in the incidence of pneumonia in the vitamin E group (95 percent CI: 31%-89%), the benefit also occurred in men who smoked more than 20 cigarettes per day at baseline or did not exercise.
Although there is strong evidence that vitamin E is good for pneumonia in older men in this analysis, the overall findings on vitamin E have been mixed.
it is necessary to explore the effects of vitamin E use in non-smoking older men.
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