Clin Microbiol Infect: Urine extract and ibuprofen as alternative treatments for non-complex urinary tract infections in women

The purpose of this study was to explore whether providing a cure (Uwe-urce or ibuprofen) while delaying a prescription could alleviate symptoms and reduce the amount of antibiotics used in adult women with acute non-concurrent urinary tract infection (UTI)a 2 x 2 factor controlled randomized trial in primary health care institutionsThe participants were 382 women aged 18-70 who had difficulty urinating, urinary emergency, frequent or urinary frequency, and who were suspected by clinicians to have a urinary tract infection (UTI)Interventions are recommended for uremia extracts and/or ibuprofenAll women were given delayed or 'back-up' antibiotic prescriptionsThe missing data were estimated using multiple induction method (ISRCTN registration form: ISRCTN43397016)AN ITT analysis of the average score of frequency symptoms assessed on days 2-4 found no evidence of a difference of -0.06 (95% CI-0.33 to 0.21; P 0.661) between Uwe-ursiand and placebo, nor evidence of a difference between ibuprofen and ibuprofen recommendations -0.01 (95% CI-0.27 to 0.26; P.951)There is no evidence that the use of efa-urine antibiotics decreased (39.9% vsPlacebo 47.4%; logistic regression winning ratio (OR) 0.59 (95% CI 0.22 to 1.58; p 0.293), but ibuprofen recommendations significantly reduced (34.9% vsno recommendation 51.0%; OR 0.27 (95% CI 0.10 to 0.72; p.009)There were no safety issues and no seizures of upper respiratory tract infections were recordedin general, the results found no evidence that interventions had an impact on the severity of frequency symptomsThere is evidence that the recommended use of ibuprofen reduces the amount of antibiotics without increasing complicationsFor every seven women who receive this advice, one less antibiotic is used