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Clin Nutr: Zheng Liangrong's team from the First Affiliated Hospital of Zhejiang University found that high dimensional C levels can reduce the risk of cardiogenic stroke and Alzheimer's disease!

 Last Update: 2021-10-20
 Source: Internet
 Author: User

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Previous observational studies have reported that plasma vitamin C levels and heart vascular disease (CVD) and Alzheimer disease (AD) has some relevance; however, to date, have not yet come out of what conclusive results
.

Heart blood vessels

Zheng Liangrong, director of the Department of Cardiology, Zhejiang University First Affiliated Hospital, led his team to conduct a Mendelian randomized (MR) study to explore the relationship between vitamin C and 9 cardiovascular diseases (coronary artery disease [CAD], myocardial infarction [MI], atrial fibrillation) [AF], heart failure [HF], stroke , ischemic stroke [IS] and IS subtypes) and the causality of Alzheimer’s disease risk
.

Myocardial infarction heart failure stroke

A recent genome-wide meta-analysis (n=52018) identified 11 single nucleotide polymorphisms (SNPs) that can be used as instrumental variables for plasma vitamin C levels
.

Extract summary-level data of CVD and AD from genome-wide association studies ( GWAS )

GWAS

Correlation between Vitamin C Level and Risk of Cardiac Stroke

The results of the analysis found that the genetic predisposition to high vitamin C levels is associated with a lower risk of cardiogenic stroke (odds ratio for every 1 standard deviation increase in plasma vitamin C levels [OR] 0.
773, 95% CI 0.
623-0.
959; p=0.
020 ) and the risk of Alzheimer's disease (OR 0.
968, 95% CI 0.
946-0.
991 ; p = 0.
007) correlation
.

Sensitivity analysis yielded similar results

A genetic predisposition to high levels of vitamin C and a lower risk of cardioembolic stroke high vitamin C levels of genetic predisposition and a lower risk of cardiac stroke and Alzheimer's disease risk and the risk of Alzheimer's disease -related related

Correlation between vitamin C levels and the risk of Alzheimer's disease

In summary, the study provides evidence supporting the association of high vitamin C levels with a reduced risk of cardiogenic stroke and Alzheimer's disease
.

However, there is no evidence that vitamin C levels affect the risk of coronary artery disease, myocardial infarction, atrial fibrillation, heart failure, stroke, stroke subtypes, large artery stroke, or small vein stroke

High vitamin C levels are associated with a reduced risk of cardiogenic stroke and Alzheimer's disease High vitamin C levels are associated with a reduced risk of cardiogenic stroke and Alzheimer's disease

Original source:

Chen Lu,Sun Xingang,Wang Zhen et al.

The impact of plasma vitamin C levels on the risk of cardiovascular diseases and Alzheimer's disease: A Mendelian randomization study in this message

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