Clin Nutrition: Feces of undernourished colorectal cancer patients accelerate cancer progression

Colorectal cancer (CRC) is one of the most common malignancies, however, the pathogenesis of CRC remains unclear
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Among all gut environmental factors, gut microbiota plays a major role in CRC progression

Colorectal cancer (CRC) is one of the most common malignancies, however, the pathogenesis of CRC remains unclear

 

To this end, in this work, the researchers prepared a subjective global assessment (PG-SGA) tool and 16sRNA sequencing to detect changes in gut microbiota and the association between nutritional status and gut microbiota
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(Redundancy Analysis/Canonical Correspondence Analysis) RDA/CCA analysis was used to assess the relationship between fecal microbiota and clinical nutritional indicators from malnourished CRC

 

The findings revealed significant differences in the fecal microbiota of patients with different nutritional status, and the researchers found that specific microbiota species, namely Atopobium v​​aginae, Selenomonas sputigena, and Faecalibacterium prausnitzii, may be considered diagnostic biomarkers of malnutrition, suggesting that poor prognosis
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Compared with the low expression level, the high expression level of A.

tumor immunity

Figure: Stools from malnourished colorectal cancer patients worsen disease outcomes

 

This study demonstrates that the fecal microbiota in CRC under malnourished conditions exhibits specific features that accelerate CRC progression and regulate B cells and macrophages
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The use of specific fecal microbial species may be a viable approach to identify malnutrition status in patients and demonstrate poor prognosis in CRC

This study demonstrates that the fecal microbiota in CRC under malnourished conditions exhibits specific features that accelerate CRC progression and regulate B cells and macrophages

 

Original source:

XuChao.

Faeces from malnourished colorectal cancer patients accelerate cancer progression.
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