It has been documented that vitamin D deficiency is associated with an increased risk of dementia.
In order to validate this evidence and determine whether vitamin D can actually play a role in early prevention of neurodegenerative changes, the researchers conducted a fluid study that looked at the relationship between vitamin D status and brain tissue, mass of the mass of the sea mass, white matter integrity, and markers of CSVD in people without dementia, and analyzed it accordingly.
cross-sectional analysis, researchers collected 2,716 dementia-free participants for serum 25 (OH) D concentration assessments and brain magnetic resonance imaging (MRI) scans from 2006 to 2009.
The main observations include brain tissue volume (total, white mass, gray mass, and sea mass volume), white mass integrity (fractional anthomorxuality (FA) and average diffusion rate (MD)) and CSVD markers (white super strength (WMH) volume, internal cavity, and micro-bleeding).
used multivariate linear and logical regression models to assess the association between vitamin D status and these brain measurements and adjusted them to lifestyle and other disease risk factors.
results showed that vitamin D deficiency (25(OH)D-lt;30 nmol/L) was independently associated with smaller brain tissue volumes, smaller white mass volumes, and smaller sea mass volumes compared to adequate vitamin D status (≥50nmol/L).
, the status of vitamin D is independent of gray matter, white matter integrity, or CSVD markers.
, vitamin D deficiency is associated with smaller brain tissue volumes and sea mass volumes, the researchers concluded.
further research is needed to clarify the role of vitamin D in neurodegeneration.