echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Endocrine System > Clin Pharmacol Ther: The use of GLP-1 RA and DPP-4 inhibitors in patients with type 2 diabetes is associated with an increased risk of intestinal obstruction

    Clin Pharmacol Ther: The use of GLP-1 RA and DPP-4 inhibitors in patients with type 2 diabetes is associated with an increased risk of intestinal obstruction

    • Last Update: 2021-10-20
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    In the process of exploring the treatment of diabetes , many large studies have found that intensive hypoglycemia can control blood sugar levels for a long time, and reduce the risk of patients with macrovascular and microvascular complications and diabetes-related end events


    Diabetic blood vessels

    Glucagon-like peptide-1 receptor agonists (GLP-1 RA) and dipeptidyl peptidase-4 (DPP-4) inhibitors may increase the risk of intestinal obstruction, but there is no real evidence of this serious adverse event


    Therefore, the purpose of this study was to determine whether GLP-1 RA and DPP-4 inhibitors are associated with an increased risk of intestinal obstruction compared with sodium-glucose cotransporter-2 (SGLT-2) inhibitors


    Experimental method experimental method

    We use the UK clinical practice research data link and link database to assemble two new user, active control cohorts (2013-2019)


    Experimental results

    Experimental results Experimental results

    Compared with SGLT-2 inhibitors, GLP-1 RA is associated with an increased risk of intestinal obstruction (1.


    Compared with SGLT-2 inhibitors, GLP-1 RA is associated with an increased risk of intestinal obstruction.


    Conclusion conclusion

    In this large real-world study, GLP-1 RA and DPP-4 inhibitors were associated with an increased risk of intestinal obstruction


    In this large real-world study, GLP-1 RA and DPP-4 inhibitors were associated with an increased risk of intestinal obstruction


    Original link: https://pubmed.


    Original link: https://pubmed.


    2021 Sep 29.
    doi: 10.
    1002/cpt.
    2430.
    Leave a message here

    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.