Clin Rheumatol: The clinical characteristics of SAPHO syndrome in children were first reported in China.

SAPHO (synovitis-acne-pustulosis-hyperostosis-osteomyelitis syndrome), short for glioartitis, acne, pustules, bone fat, myelitis syndrome.
, acne, pustules, bone fat, myelitis syndrome is an abbreviation for the following 5 English words, namely: synovitis( synovitis), acne (acne), pustules (pus) Hyperostosis and myelitis, pustules, bone fat, myelitis syndrome is a chronic disease that mainly affects the skin, bones and joints.
age of onset is in youth and middle age.
age of onset is at least 10 years.
, however, there was little information on SAPHO syndrome in children in the past.
, childhood SAPHO syndrome is considered equivalent to chronic relapsed polysexual myelitis or chronic non-bacterial myelitis.
study aims to assess the clinical characteristics and treatment options of SAPHO syndrome in Chinese children.
the study was conducted by a team of professors at the Concord Hospital Single Center in Beijing, China.
researchers conducted a single-center retrospective study of 24 children with SAPHO syndrome diagnosed at Concord Hospital in Beijing from April 2014 to August 2018.
data collected and analyzed in demographics, clinical, laboratory, imaging, histology, and therapeutics.
15 of them were boys and 9 were girls.
age of onset of bone and skin symptoms was 11.7±3.8 years and 14.4±2.7 years, respectively, with an average follow-up time of 39.2 months.
17 patients had skin manifestations (46 per cent had severe acne, 100 per cent were boys; 21 per cent had palm-plant pustules and 100 per cent were girls).
lesions are located in four main areas: the frontal chest wall (42%), the jaw (29%), the outer bone (50%) and the spine and sa joints (21%).
6 patients received nonsteroidal anti-inflammatory drugs, 10 received bisphosphonate therapy, 10 received tumor necrotogenic cause-α antagonist treatment, and 1 patient received glucodermal hormone therapy, but the response was different.
70% of patients were α treated with bisphosphonates or TNF-α antagonists.
above results show that children with SAPHO syndrome have different characteristics than other groups in terms of sex ratio, frequency of jaw injury and gender distribution of skin lesions, showing more men than women.
same time, studies have also observed that bisphosphonates and TNF-α antagonists showed good therapeutic response in the treatment of SAPHO syndrome in children.
: This study is the first in a series describing SAPHO cases in children in Asia.
chinese children with SAPHO syndrome have different characteristics from Chinese adult patients and Caucasian children.
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