Clin Trans Gastroenterology: Gastrointestinal symptoms in new coronavirus infections are associated with the prognostode of the disease

The new coronavirus COVID-19 is an RNA virus belonging to the β coronavirus family, and the current global coronavirus outbreak is not clearly under control and has resulted in a large number of patient deaths.
The new coronavirus enters the host cell through transmeanthrene serine protease and angiotensin-2 (ACE2) complexes, which are expressed not only in the pulmonary epithelial cells, but also in the esophoid, small intestine and colon epithelial cells.
addition, about 50% of COVID-19 patients also excrete the virus in their faeces, and a study from China showed that viruses were present on the surface of the gastrointestinal tract (GI) where ulcers were present and in gastrointestinal biopsies.
, COVID-19 infections affect not only the respiratory tract, but also the gastrointestinal tract, with one study reporting that 28 percent of patients develop gastrointestinal symptoms even without respiratory symptoms.
Therefore, this study aims to provide a forward-looking study of (i) the frequency and extent of gastrointestinal symptoms in patients infected with COVID-19 infection, (ii) factors associated with gastrointestinal symptoms, and (iii) the relationship between gastrointestinal tract and the symptoms, severity and prognostic relationship of COVID-19.
researchers assessed the clinical performance of patients with COVID-19 infection in a university hospital laboratory in northern India, including gastrointestinal symptoms, their predictive factors and the relationship between the presence of these symptoms, the severity of the disease, and the results of single-factor and multi-factor analysis.
results showed that between April 2020 and May 2020, COVID-19 RNA was detected in 16,317 subjects' mouth and nasopharyngeal swabs, of which 252 (1.5%) had positive symptoms.
208 of them (82.5%) were asymptomatic.
of the 44 patients with symptoms, 18 (40.9%) had non-gastrointestinal symptoms, 15 (34.1%) had gastrointestinal and non-gastrointestinal symptoms combined symptoms, and 11 (25.0%) had gastrointestinal symptoms alone.
33 cases were mild to moderate, 8 severe and 5 severe.
five patients (1.98%) died.
in multivariable analysis, factors associated with gastrointestinal symptoms include a history of exposure and a combination of non-gastrointestinal symptoms.
patients with gastrointestinal symptoms were more likely to suffer from severe critical illness and fatal clinical prognosis than patients without gastrointestinal symptoms.
the study, researchers found that 88 percent of patients were asymptomatic coVID-19 infections and 10.3 percent had gastrointestinal symptoms.
5 per cent and 2 per cent, respectively, are serious and fatal.
the presence of gastrointestinal symptoms is associated with severe diseases and fatal results from multi-factor analysis.