Clin Trans Gastroenterology: Gender-related gene expression changes are associated with the lifetime of esophageal cancer

Esophageal cancer (EC) is an important cause of cancer death, with a five-year survival rate of 10% to 15%, esophageal cancer (EC) in the United States in 2020 was diagnosed as the sixth most common digestive tract cancer, is the fourth most common cause of death of gastroesophageal cancer, EC has two different subtypes, squamous cell carcinoma and adenocarcinoma, each subtype has a unique pathogenesis.
risk factors for squamous cell carcinoma include smoking and alcohol consumption, while gastroesophageal refratic disease and obesity increase the risk of adenocarcinoma.
Both types of cancer are male-dominated, with men more severely affected by esophageal cancer, men more likely to die of EC or lower survival rates once diagnosed, and men have poor prognosis in EC regardless of surgery.
Cancer Genome Map (TCGA) dataset can be used to assess potential prognostic markers in large patient queues.
, the purpose of this study is to use the TCGA EC dataset to assess whether survival rates vary by sex and to explore genetic changes that may explain the observed variation.
by searching the TCGA Clinical/RNA-seq data set, it was found that in EU countries, high levels of cancer in men and esophageal cancer reduced the overall survival rate of patients (2.27 times higher mortality rates for men than for women.
high-level tumors are 2.49 (0.89-6.92) higher than low-level tumors), for non-resuming rates (4.09 times higher for men than for women (0.98-17.03) and 3.36 times higher than low-level tumors (0.81-14.01).
to investigate the genetic basis of gender-based survival differences in EC, the corresponding gene expression data were analyzed.
Tested by Wilcox, there were 69 genetic disorders, of which the X chromosome base was 33% and the Y chromosome base was 7%.
, this study confirms that women may have a survival advantage in EC.
important, we demonstrate the genetic/esoic basis of these survival differences, which are independent of the lifestyle-related risk factors represented by men.