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The most common metastatic target organ for colorectal cancer (CRC) is the liver.
the initial diagnosis found that about 15% to 20% of CRC patients have liver metastasis, the remaining 60% of patients in subsequent treatment will also appear liver metastasis or tumor recurrence, which is the CRC treatment of poor efficacy and the main cause of death.
overextendation of phosphatases in regenerative liver 3 (PRL-3) and endoskine-interstitium transformation (EMT) is considered to be the most important factor affecting distant metastasis of tumor cells, and is associated with CRC migration, invasion and metastasis.
in this study, the researchers used CanPatrol CTC rich technology and PRL-3 antibody probes to pinn up mobile tumor cells (TCCs) and divided CTC into three sub-groups, namely, the skin CTC with PRL-3 (E-PRL) -3 plus CTC), dual esothype overskin/interstate with PRL-3 CTC (E s/ M s PRL-3 s CTC) and interstate CTC with PRL-3 (M s PRL-3 s CTC).
study aims to explore the prognostic significance of PRL-3 (M -PRL-3 plus CTC) and interstitcharged CTC in postoperative CRC patients.
researchers tested CTC subtypes (including endothystic CTC, double esothypeal/intersuper charge CTC and interstate CTC) and PRL-3 from exothentic blood samples from 156 patients.
then performed subject work characteristic curve analysis, Kaplan-Meier analysis, and Cox proportional risk regression analysis to identify the prognostic value of PRL-3 plus interstit rated CTCs.
immunologic tissue chemistry is used to detect the expression of PRL-3 in some patients' tumor tissues to explore the link between CTC and tissue.
found that all CTC in all samples were positive, as were interstate CTC and PRL-3-positive cells.
the count of interstate charge and PRL-3 plus CTC is significantly corred with recurrence, with an optimal threshold of 2 (area below the curve: 0.690, P -lt;0.001).
addition, based on multivariable and polynolytic logic regression, the median survival of these patients was significantly shorter than that of patients who did not meet the standards (8.5 vs 24 months, P .lt;0.001).
, this study confirms that the status of M-PRL-3-plus in CTC may be an important prognosmical indicator for evaluating CRC clinical outcomes.
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