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    Home > Active Ingredient News > Digestive System Information > Clinical Gastroenterology H: Plasminogen activator inhibitor-1 can be used as a marker for changes in esophageal function in children with eosinophilic esophagitis

    Clinical Gastroenterology H: Plasminogen activator inhibitor-1 can be used as a marker for changes in esophageal function in children with eosinophilic esophagitis

    • Last Update: 2022-01-08
    • Source: Internet
    • Author: User
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    The incidence of eosinophilic esophagitis (EoE) is increasing in children and adults
    .


    It is characterized by the clinical and histological consequences of chronic Th2 immune- mediated inflammation and the resulting esophageal dysfunction


    The incidence of eosinophilic esophagitis (EoE) is increasing in children and adults


     

    The researchers collected esophageal biopsy samples from EoE and healthy people, and isolated and cultured primary human esophageal epithelial cells for PAI-1 immunohistochemistry and cell proliferation experiments
    .


    PAI-1 immunostaining and basal cell hyperplasia were evaluated in the context of endoscopic imaging probe (EndoFLIP) esophageal compliance measurement


     

    The results of the study showed that 45 children (32 with EoE and 13 without EoE) were measured with EndoFLIPs and found that compared with inactive or control patients, the epithelial PAI-1 of patients with active EoE was significantly increased (P< .
    01 p eoe ci pai-1>

     

    This study confirmed that PAI-1 is significantly elevated in children with EoE and can be used to distinguish changes in children's esophageal compliance
    .


    Therefore, PAI-1 may be a new disease marker and therapeutic target


    Original source:

    Prerana Williamson.
    Et al.
    Plasminogen Activator Inhibitor-1 as a Marker of Esophageal Functional Changes in Pediatric Eosinophilic Esophagitis.
    Clinical Gastroenterology and Hepatology.
    2021 .

    <.
    01 p eoe ci pai-1>

     

    This study confirmed that PAI-1 is significantly elevated in children with EoE and can be used to distinguish changes in children's esophageal compliance
    .


    Therefore, PAI-1 may be a new disease marker and therapeutic target


    Original source:

    Prerana Williamson.
    Et al.
    Plasminogen Activator Inhibitor-1 as a Marker of Esophageal Functional Changes in Pediatric Eosinophilic Esophagitis.
    Clinical Gastroenterology and Hepatology.
    2021 .

     

    This study confirmed that PAI-1 is significantly elevated in children with EoE and can be used to distinguish changes in children's esophageal compliance
    .


    Therefore, PAI-1 may be a new disease marker and therapeutic target


    This study confirmed that PAI-1 is significantly elevated in children with EoE and can be used to distinguish changes in children's esophageal compliance


    Prerana Williamson.


    Plasminogen Activator Inhibitor-1 as a Marker of Esophageal Functional Changes in Pediatric Eosinophilic Esophagitis.
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