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Clinical Nutrition: Body composition parameters can predict the prognosis of locally advanced gastric cancer patients after receiving neoadjuvant therapy

 Last Update: 2021-08-02
 Source: Internet
 Author: User

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Patients with gastrointestinal tumor surgery often suffer from sarcopenia and visceral fat obesity, and body composition characteristics affect the prognosis of many cancers; body composition is locally advanced after neoadjuvant therapy (NT)The role of gastric cancer (LAGC) in patients has not been well studied.
Therefore, this study aims to measure body composition in patients with locally advanced gastric cancer after neoadjuvant therapy to predict their disease prognosis
.

Researchers performed related examinations on 213 patients in southern China, all of whom were LAGC patients who underwent post-NT gastrectomy
.

In addition, external verification was performed on 170 patients from western China and 77 patients from Italy

diagnosis

In general, all patients did not have any significant changes in body composition parameters after receiving NT
.

The pre-NT skeletal muscle radiodensity (SMD) and SMI changes (ΔSMI) were significantly reduced in patients with poor response.

This study confirmed that for LAGC patients, SMD and ΔSMI levels before NT treatment can accurately predict the pathological response after NT
.

SMI loss >1.

This study confirmed that for LAGC patients, SMD and ΔSMI levels before NT treatment can accurately predict the pathological response after NT

Original source:

Jian-Xian Lin.

Body composition parameters predict pathological response and outcomes in locally advanced gastric cancer after neoadjuvant treatment: A multicenter, international study.

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