Clinical Nutrition: The Mediterranean diet reduces the formation of atherosclerosis in patients at high cardiovascular risk

Background and target circulating microcystic bubbles (cMVs) are small phospholipid-rich vesicles that contribute to the formation of atherosclerosis and are biomarkers of cardiovascular disease (CVD) burden and progression.
diet is the cornerstone of prevention of CVD, but the characteristics of the effects of diet on cMV shedding are not yet clear.
study aims to assess the long-term effects of the Mediterranean diet on MV shedding in blood and vascular chambers in patients with high cardiovascular risk compared to low-fat diets (LFDs).
155 participants in this study followed them for an average of 5 years (53 patients were given extra virgin olive oil-EVOO in the Mediterranean diet; 49 were added to the Mediterranean diet with new olive oil); and 53 received the LFD diet).
After baseline and one year of intervention, cMV was quantitatively and qualitatively analyzed by fluid cytometology to identify the source of the living progenitocytes and the potential for thrombosis through membrane-linked protein V (AV) binding.
results after a year of dietary intervention, compared to LFD and EVOO intervention, the small plateboard-based lymphocyte functional inhibitors PAC-1-plus/ AV-plus and lymphocyte CD62P-plus/AV-cMV concentrations were lower (P-0.036 and 0.003).
addition, pre-thrombosis cMV carrying tissue factors (CD142 plus / AV plus) and CD11a plus / AV plus cMV in Mediterranean dietary interventions were lower than LFD (P.lt;0.0001 and 0.028).
concluded that cMV is a marker of cellular activity and vascular damage that appears to be sensitive to dietary changes.
patients who follow a Mediterranean diet rich in EVOO or nuts will develop an active factor accompanied by lower cell-to-atherosclerosis thrombosis pre-hydration hydrants.