Cloned pet dog pockets are controversial, DNA-like but cannot replicate the soul.

After really starting the cloning program, wang Yiqing, the owner of the pet dog "go around", felt some "anxiety".
no matter how many times heard the story of the cloned sheep Dolly, when the real clone out of the young, soft "new pocket" in the hand, Wang Yiqing or some what at a loss. "The worldview was a big shock when I saw the technology that lives alive,"
said.
", in fact, cloning a dog is a complex matter from both a technical and ethical point of view, and there is no shortage of controversial ambiguity.
but in any case, cloning technology has passed through time and space, came to you and me.
"Magic Experience" is a white Sinari, 12 years old.
interview day, Wang Yiqing took his pocket to the company's office to meet with reporters.
for this kind of dog, the ride has reached the age of the Nishi Mountain.
its hair color began to have some gray, and now even the steps of the car can not cross, each time with the front paws pick the car edge, and so the master Wang also clear lying up.
Wang Yiqing wore a pair of black half-framed glasses, wearing a large white striped shirt, cuffs open at will, hands from time to time to touch a pocket lying at the feet.
", "Sinari can generally live to the age of fifteen or six.
," he said.
they had been together for 11 years, and they never had to learn the skills of slinging arches, "it's better to make a dog live as a dog."
Wang Yiqing regarded it as a family member, party trips with it, his WeChat head is a picture of a pocket.
from the moment he lost his first tooth at the age of seven, he began to worry about what to do when it came to the end of his life one day.
Wang Yiqing heard that South Korea has cloned dog technology, a little heart-throb, looking forward to when China can also achieve.
what he thought of, Mi Jidong, had already started to do.
", "We are Tsinghua Management EMBA classmates, he introduced himself said to do clone dogs."
" Wang Yiqing met Mi Jidong, general manager of Beijing Shino Valley Biotech Co., Ltd., which was the beginning of his "magical experience" of cloning his pet dog.
Mi Jidong's team is currently the only scientific research team to master cloned dog technology, they officially launched a commercial project in August 2017 for ordinary people to clone dogs.
Wang Yiqing was one of the first to eat crabs.
May 31, 2018, researchers took a small piece of skin tissue from their pockets at a pet hospital, ready to do somatic cell cloning, "like a cut in the skin."
but this seemingly simple operation, to Wang Yiqing brought a series of worries: "Dogs are not monolets, if cloned out of 4 how to do?" DNA can be copied, but 12 years of growth can not be replicated, now our living environment and habits have changed, the dog's character will be the same? Now the pocket is still there, the relationship between the new pocket and the pocket is how to define? Even if DNA is the same, hair color may be different, what if it looks different? But if it looks exactly the same, and so on, I see the new pocket will be happy or sad? "Technology is clearly ahead of these concerns.
Wang Yiqing has not figured out, more than two months later, the new pocket was born.
the puppy had not opened its eyes, the staff came up with the photo.
Wang Yiqing looked: "How is it dark?" Most of the hair of the new pocket body is flaxy, with nearly black on the mouth and hips and inside the legs.
went around more than a year old to Wang Yiqing's home when the hair white, he suspected that is wrong. Two cloned dogs were born on the
day.
has been compared by DNA and proved to be not wrong.
the DNA of the new pocket and the pocket in the photo.
Wang Yiqing began to look into the information, "it is said that Sinari was born dark."
he turned to his pocket and said, "Look, that's what you did when you were a kid!" "The worry adds a little bit of unamentonous joy and intimacy.
newborn clone dogs need to be under the care of researchers for two to three months before they can be delivered to Wang Yiqing.
during this period, he went to the Chino Valley company to see the new round a few times.
" didn't seem to feel anything when I first saw it.
" Wang Yiqing looked a little confused.
"How do you expect it?" The reporter asked.
" is not clear.
maybe the smell should be similar? He said.
", "What name are you going to give it?" The reporter asked.
usually pet owners choose to clone after the death of their pet, and the newborn puppy will naturally inherit the name of the cloned dog.
" hasn't thought about it yet.
", Wang Yiqing temporarily called it a "new pocket" or "small pocket".
he stood less than a meter away from his pocket with his new pocket, raised the little guy to look at it, and said to him, "Look who this is?" "There's no response to the ride.
sister? Mother and daughter? In fact, Wang Yiqing himself can not answer this question.
but for Wang Yiqing, the new pocket is much more intimate than other puppies.
he crouched in front of his new pocket and surrogate mother's cage, watching the little guy stumble down in a feeding bowl as big as his own, and smiled with pride and said to others, "Stand still and grab someone else's food."
like! That's like! "The "living technology" is not the same as the customer's most concern.
", Dr. Feng, head of the laboratory at Chino Valley, told China Youth Daily Zhongqing Online. Dr.
Feng, 37, has a hot mid-cut hairstyle from the early 1990s and is very talkative with a pair of thin-framed glasses.
he has been working on somatic cell cloning pigs, and after graduating from the Beijing Institute of Livestock and Veterinary Medicine of the Chinese Academy of Agricultural Sciences, he moved to the company to study cloning and gene-editing dogs.
there is a password door at the edge of the grid of the Shino Valley Clone Division, Dr. Feng swipes into, changes into light blue coats and slippers, and takes the reporter into the cloning lab.
"are genetically identical.
," he said.
technology guarantees this.
somatic cell cloning dog technology is also known as somatic cell nuclear transplantation technology, in layout, is the donor (i.e. cloned body) body cell nucleus out, placed in a go-to nucleocellular, after artificial activation, and then the simulated fertilized egg formation of the embryo into the surrogate dog mother's body, so as to breed cloned dog.
because the nucleus provides the same genetic material DNA, the cloned product is "exactly the same" as the donor.
several functional partitions of the Chino Valley Laboratory correspond to the above steps.
the operation between the preparation room and the operation room next to each other, the researchers after the emotional identification confirmed that the donor dog egg cells can take the egg, the donor dog to the operating table to "flush the egg."
the operating table is made of two metal plates, forming a blunt angle in the middle that reflects the cold light of the metal.
the operating room also has anaesthetic machines, ventilators, monitors and other equipment. After
removed the eggs, the researchers sent them through a window into the cell chamber to build the embryo.
the cell preparation chamber and the cell chamber together.
cell-related operations such as cell nuclear separation of cloned dog cells and the preparation of cloned embryo culture fluid are carried out here.
blue cabinet is placed on the osmometer, high-precision balance, magnetic agitator and other equipment.
donor cells of the nucleus and denuclearized egg cells in the cell chamber fusion, activation, the successful lysaced cloned embryos are sent back through the window back to the operating room, the researchers will be cloned embryos into the surrogate dog mother.
surrogate mother uses an experimental animal bigg dog. After
confirmed the pregnancy, the surrogate dog mother was sent to the delivery room for delivery.
if the baby is successfully born, the mother and puppy will be sent to the nursery.
interview day, there are more than a dozen dog cages in the delivery room, the door is facing a cage a dog mother's stomach fell drumfully under the body, slowly pacing, ignoring the visitors. Dr.
said that their cloned pregnancy rate is now more than 50%, that is, cloning a puppy generally requires about two surrogate female dogs.
clone pocket is also the launch of two surrogate mother dogs.
the situation in the nursery is much more lively than the waiting room, the door three clone big dogs pickpocketed cage jumping up and down, excited to the reporter's lens.
the new pocket of the cloned dog only a pair of hands, but also softly squeezed under the surrogate dog mother's legs, was placed in the room the most inside.
China is the second known country in the world to master the technology of cloning dogs.
2005, South Korea's Hwang Kyo-sik team cloned the world's first cloned dog, Snoopy, using the body cells of the Afghan hound Tai.
compared with other cloned mammals, the reproductive system of dogs is special.
"the egg it discharges is the egg, does not have the fertilization condition, and the egg can only mature in the fallopian tube, can not be matured in vitro", which makes the time to confirm the timing of the egg retrieval, that is, to explore a complete identification technology to become the first major problem of cloning dogs. in addition, the
the procedure is also difficult to multiply due to the physiological structure of the dog. Dr.
, the dog's ovaries are not directly exposed, but are wrapped in the ovary sac, "you don't know what the state is inside", and the dog's fallopian tubes are wrapped around the surface of the ovaries, making the egg and embryo transfer process difficult to succeed.
" South Korea published the paper let us know what to do, but the specific how to do also have to find their own.
," Dr. Feng said.
March 2016, the Chino Valley research team officially began the cloning of dogs.
May 2017, China's first somatic cell clone dog "Dragon Dragon" was born here.
From March 2018, the cloning process has been standardized to the present day, Dr. Feng has cloned nearly 20 puppies, including Big, Jingba, Sinari, Bomi, VIP dogs, and more.
clone of the English "clone" has also been translated as "asexual reproduction".
data show that since 1996, when dolly, the world's first cloned mammal, was born, the technology has been successfully applied to mice, cattle, pigs, rabbits, horses, deer, ferrets, monkeys and other mammals.
, cloning technology has been widely used in many areas of animal husbandry, such as breeding selection, GM livestock production, high-quality breeding, speed up the breeding process of livestock, save endangered rare species and so on.
but scientific knowledge is not enough to touch Wang Yiqing, whose advanced papers and generally discussed animal husbandry applications are too far from the lives of ordinary people compared to pet dogs.
only with a new pocket in hand, cloning technology has become a "living technology."
cloning technology: the controversy follows Mi Jidong to see the rapid development of the domestic pet market, he hopes that cloning technology can meet the emotional appeal of pet dog owners, after the death of pet dogs, to provide them with a "psychological support."
however, the development and application of cloned animals has been accompanied by controversy, people pay attention to the dual challenges of technology and ethics.
the cloning of animals technology still has some questions, such as the hair color of cloned dogs.
"The biggest expectation is that the new pocket looks the same as the one.
" Wang Yiqing told reporters, but he knew that "DNA is exactly the same" and must be the same as "looking exactly the same."
"the DNA sequences of cloned animals are exactly the same, but there are many modifications on the DNA that cannot be completely replicated, and there may be subtle differences in the hair color of cloned animals." "But the difference between cloned animals is like identical twin sisters or brothers, and similar physical characteristics can give the owner some comfort and identity, " said Professor Kwon Fusheng of the School of Animal Medicine at Northwestern University of Agriculture and Forestry,
.
", "but even if some are not the same can accept it, after all, science is that way we know."
, " said Wang Yiqing.
Science, it says there is no evidence that cloned dogs and cloned dogs have the same character.
"The brain is so long, should be more like it?" Wang Yiqing still hope that the new pocket in the next life can be more and more like a pocket, "take a step by step to see it."
the emergence of cloned dog technology in Korea, there is a worldwide precedent for cloning dogs.
some people think that this is a good way to rely on emotion; others say it is a self-deception "scam", DNA is as meaningless as "cannot replicate the soul". Qiu Renzong, a researcher at the Institute of Philosophy of the Chinese Academy of Social Sciences
, agrees with the latter.
he believes it is time to "prohibit the waste of research funds on dead pets that are virtually non-replicable."
others have spoken out against cloning dogs because of concerns about the ethics of harming dogs.
"I am firmly opposed to human cloning because he has no ethical position."
," Dr. Feng said, "but the ethical relationship between the animal world is less obvious."
" Kwon Fusheng also believes that the ethical relationship between animals may not be the focus of attention.
"The phenomenon of inbreeding of animals is widespread under natural conditions, and the blood relationship between animals only affects their genetic properties, and may not have a very important impact on the social relationship between animals".
"as far as ethics is concerned with whether animal ethics is carried out in accordance with the requirements of animal ethics in the process of animal breeding and use.
rather than consider ingons of human ethics.
," Kwon said.
discussion of cloning dogs, a bioethicist has pointed out that the key may be what pet owners think they have got when they clone a beloved animal. wang Yiqing,
, concludes that there may be three things about his doing: "My practice shows that cloning dogs are feasible;
" talk edited about the value and application of cloning technology, and Dr. Feng actually wants to focus more on cloning gene-edited disease model dogs for research to combat human diseases.
they are currently using gene editing and cloning to breed atherosclerosis model dogs and diabetes and autistic model dogs as experimental animals, supplying hospitals and scientific research.