Closer to big curry: Cohansen's thinking on probiotic industry and the ® of LGG and lactobacillus lipos

This is the best of times, and the worst of times
"Dickens's golden phrase, recently became Lin General (Cohanson's senior sales manager for health and nutrition in China) in the face of industry colleagues.long-term struggle in the front line, operating a rapid growth every year, from consumers to the investment community unanimously popular probiotic market Lin, in the song and dance under the rise of what calm thinking? Recently Zhuang (
Z
) and Lin General had a dialogue and recorded it, let us layer by layer to open Lin's general thoughts, decrypt his views on the development of the industry.summary: Three key points to remember lfor the healthy development of the industry, probiotic products need to be identified to strain number and specific efficacy, and need to be supported by clinical literature.cottage
LGG
due to production process defects, in terms of efficacy and Cohanson original
LGG®
rat l.lycide lactobacillus can not be the same day.lcustomers as well as friends need to standardize the naming
LGG ®
and cottage products to draw a clear line. Use the official product name:
LGG ®
LGG, Lactobacillus liposaccharide. At the same time, it is necessary to indicate the authorized trademark in the appropriate place of packaging.Z
: Lin, recently found that other departments congratulate you on your performance, you all take the two sentences of the double city record to the end. We think there must be some stories behind it, can you tell it and listen to it?: Don't tell you, chest pressure two mountains, really don't vomit unhappy, but say you have to help me organize, published on the company's public number.Z
: No problem, would like to hear about it.: Two mountains, one is in the face of the influx of enterprises and practitioners, how to rational development to ensure sustainable growth of the industry. The second one is actually the first, but the problem is very troubling:
the
of LGG bacteria occurs frequently.the probiotic industry thinking Z
: Can you first say the first, in the face of the wind mouth fishing in other industries is a very common phenomenon, that in the probiotic industry is the specific performance of what? How do we extend the life of the industry, or do we make a swimmer who always keeps leggings?Lin General: How fast the probiotic industry is developing now: I now travel to the fourth and fifth-tier cities, ask some young mothers, when the baby has diarrhea, allergies and other conditions, she will answer you,
"
eat probiotics ah, a pack will not pull the stomach.
"
people feel that such rapid development thanks to strong efficiency and good word-of-mouth.recently, some manufacturers and grass-roots sales have begun to put the probiotic myth. Either under the guise of

probiotics" exaggerated efficacy, or at the time of sale to consumers
"
I this product to cure a hundred diseases
"
impression. Three is to the industry mine behavior ah, different consumer situations and needs are different, such a brutal propaganda, will only bring such as no effect

,
"
effect is not obvious
"
and even side effects of negative word-of-mouth. you have been to the company for some time, I test you: to measure the efficacy of a probiotic to what extent? Z
: Strain. diagram: Genus, strain and strain relationship lin total: yes, I'll give you an example:
GR-1™
Rat Lactobacillus and
LGG®
Rat Lactobacillus. Their genomic analysis showed that the genetic similarity between the two
98%
, but not entirely consistent. But it is the results of clinical trials in this area of
2% of the genetic differences that are less than
:
GR-1™
rats have a definite effect on bacterial vaginitis, while numerous clinical trials of
LGG®
rats have shown that
LGG®
LGG mice, had a significant effect on gastrointestinal and immune health, but did not improve the effect of bacterial vaginitis. addition, if only the safety experiments and animal experiments of the products into the market, to avoid clinical trials to verify the human effects, which is also the the market seedlings. So, we are also calling on all parties, in order to sustainable growth of the industry, but also to give consumers real health products, for probiotic health food must be identified accurate to the strain, while clearly adapting to the scene. To quote the words commonly used by programmers
Talk is
,
show me the strain.
(There's no reason for the mouth to say, the strain number shows out). Z
: So how's it going? Lin General: Now the State Administration of Market Supervision and Administration of the Probiotic Health Food Declaration and Review Provisions (Draft for Comments), of which Article 4 has mentioned that

applications for probiotic health food, in addition to the "Health Food Registration and Filing Management Measures" and other relevant provisions to submit declaration information, should also provide relevant information on strains and strains. Its ninth point more clearly pointed out the need to provide,
"
strains in the plant level has a functional role in the research reports, scientific literature, such as Although still a draft, but the signal is still very strong, I hope that the major responsible, progressive related enterprises, experts can reach a consensus to create a good market environment. true
LGG ®
strain Z
: Just now we talked about the strain number, mentioned
LGG ®
. Can you say that the current shanzhai
LGG
strain and our Cohanson's
LGG®
rat Lactobacillus (hereinafter referred to as
LGG®
) is not the same product? Is there a difference in efficacy? :
LGG®
has more than
1,000
articles, can be said to be a well-deserved industry star, the United Nations Food and Agriculture Organization even for his endorsement. The name is outside, not spared, tragically cottage. Attached: FAO document: Probiotics in food (explicitly mentioned in the article
LGG®
and our other product
BB-12 ™
The strong efficacy of Bifidobacteria) but the cottage of the strain and the high imitation package, there is a significant difference in efficacy. A lot of leather bags
A
, the production enterprise itself may be the original brand of the factory, so the perfect re-engraving of the production process. However, the real
LGG ®
is the original production of Cohansen, so other enterprises can not re-engrave the original training conditions and processes. We found some products


GG"
, because the conditions for the production of fermentation are not relevant and gene loss occurs. In other words, the
"
Rat Leucose Lactobacillus
G"
and the original production of
LGG®
Rat Leucose Lactobacillus are essentially two strains. , the missing gene fragments are crucial
ISL1
and
ISL2
.
ISL1
affects sugar metabolism and sugar transport capacity, to be clear, the vitality of the strain
/
vitality, the loss of
ISL2
means the absence of
LGG
bacteria hair, affecting intestinal implantation. image:
LGG®
rat Lactobacillus under the microscope, the surface of the bacterial hair structure allows it to survive well in the human intestine. diagram: non-original production of
LGG
gene fragments are lost, purple blocks represent the
ISL1
gene affecting the ability of or saccharides, blue blocks for the
ISL2
gene affecting the production of bacteria hair. the clinical manifestations of are the inhibition of
pathogens of Hansaki E. coli, Staphylococcus acobacteria, Cystic
membrane, salmonella
, competition and exclusion, some of which do not even show inhibitory effect. And gene loss also affects the shelf stabilization period of the product. diagram: some products on the market under the

rat lactobacillus
GG"
banner of the shelf life is very poor, and
LGG®
rat lucose lactobacillus is far fromZ
: then we
LGG®
cottage phenomenon has countermeasures, how to protect the interests of customers and consumers? Lin general: First of all, to standardize the original product naming, we need to remember the official product name of
LGG®
:
LGG®
rat lactobacillus, but where the use of our original strain of customers, it is necessary to use the
LGG®
rat lucose lactobacillus this name to form a difference with cottage products. Can also consider the product in the appropriate place to label authorized registered trademarks, a total of old and new versions can be used, not only to facilitate consumer identification, but also for our screening cottage products, to maintain the market and consumer interests to provide convenience. : Old and new versions
LGG®
Rat Lactobacillus
Logo another: a summary of the content of this dialogue has been marked at the beginning. On the opportunity of this dairy annual meeting, I wish all my colleagues a new fiscal year, a hundred feet, to work together on this promising and meaningful industry.