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CMI: Immune response to SARS-CoV-2 in nursing home residents after being vaccinated with Comirnaty® COVID-19 vaccine in full dose

 Last Update: 2021-10-19
 Source: Internet
 Author: User

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Background: Elderly people are given priority for SARS-CoV-2 vaccine because they are at increased risk of severe COVID-19

Elderly people are given priority for SARS-CoV-2 vaccine because they are at increased risk of severe COVID-19

Purpose: This study aims to detect the SARS-CoV-2 immune response of two doses of Comirnaty® COVID-19 vaccine in elderly people in nursing homes

Methods: The representative sample of the prospective cohort study came from Valencia Nursing Home (n=881; male: 271, female 610; median age was 86 years), using random single-stage cluster sampling method

Results: Within 99 days (range 17-125 days) after complete vaccination, the detection rates of SARS-CoV-2-s antibodies in recovered patients and residents of nursing homes were 99.

Table 1 The SARS-CoV-2 IgG response was measured by lateral flow immunochromatography after full-dose Comirnaty® inoculation of residents of SARS-CoV-2-naïve or rehabilitation nursing homes

Table 2 Flow cytometry detection of SARS-CoV-2-S reactive T cells in nursing home residents who can detect SARS-CoV-2-S antibodies after full dose of Comirnaty® vaccination

The figure is based on the quantified sars-cov-2-S reactive antibody level and the intensity of the lateral flow immunochromatography (LFIC) IgG spectrum based on Roche Elecsys® anti-sars-cov-2-S immunoassay

The Comirnaty® new coronary pneumonia vaccine is highly immunogenic to nursing home residents

Albert E, Burgos JS, Peiró S,et al, Immunological response against SARS-CoV-2 following full-dose administration of Comirnaty® COVID-19 vaccine in nursing home residents .

Immunological response against SARS-CoV-2 following full-dose administration of Comirnaty® COVID-19 vaccine in nursing home residents

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