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CMI: Serious clinical consequences of a semi-automated system for antimicrobial susceptibility testing of carbapenem-resistant Enterobacteriaceae

 Last Update: 2022-05-17
 Source: Internet
 Author: User

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Background: Carbapenem-resistant Enterobacteriaceae (CRE) is considered a global health emergency

OBJECTIVE: In this study, we investigated the discrepancy rate of drug susceptibility testing for CRE between the semi-automated system and the reference system, and the impact of the so-called error of the semi-automatic system in guiding targeted therapy for bloodstream infection (BSI) in CRE

Methods: A multicenter retrospective study of patients with monomicrobial BSI caused by CRE from January 2013 to December 2016

RESULTS: We included 366 patients with CRE-BSI; 220 (60%) were male and the median age (IQR) was 67 years (54-76 years)

Table 1 Based on EUCAST breakpoints* of meropenem, fosfomycin, amikacin, gentamicin, colistin, and tigecycline*, 366 strains of carbapenem-resistant strains collected from 3 large tertiary teaching hospitals Minimal inhibitory distribution (MIC), MIC50, MIC90 of Enterobacteriaceae

Figure 1 Kaplan-Meier curve analysis of the impact of inappropriate targeted therapy due to misleading results from automated tests compared to aggressive therapy based on retrospective reference testing on the same strains

Conclusion: ME and VME are relatively common semi-automatic drug susceptibility testing systems

Original source: Bartoletti M, Antonelli A, Bussini L, et al.
Clinical consequences of very major and errors with semi-automated testing systems for antimicrobial susceptibility of carbapenem-resistant enterobacterales.
Clin Microbiol Infect 2022 Mar 17 Clinical consequences of very major and errors with semi-automated testing systems for antimicrobial susceptibility of carbapenem-resistant enterobacterales.

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