CMI: The effect of hydroxychloroquine alone or combined with azithromycin on the mortality of COVID-19 patients

BACKGROUND: quinoline hydroxychloroquine with or without azithromycin have been widely used to treat 2019 coronavirus (COVID-19), had on in early of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) also have in vitro antiviral effect
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Quinolin hydroxychloroquine with or without azithromycin have been widely used to treat 2019 coronavirus (COVID-19), had on in early of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) also have in vitro antiviral effect
.

Purpose: A meta-analysis to compare the mortality of patients with hydroxychloroquine with or without azithromycin and standard treatment
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The subjects of the study are patients with confirmed COVID-19, aged ≥18 years

Results: The preliminary search yielded 839 articles, 29 of which met our inclusion criteria
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With the exception of one study, all studies were conducted on hospitalized patients and evaluated the therapeutic effect of hydroxychloroquine with or without azithromycin

Table According to the ISARIC WHO CCP-UK cohort, assuming a hospital mortality rate of 26% in the UK, the relative risk and risk difference of hydroxychloroquine with or without azithromycin-related mortality

Table According to the ISARIC WHO CCP-UK cohort, assuming a hospital mortality rate of 26% in the UK, the relative risk and risk difference of hydroxychloroquine with or without azithromycin-related mortality

Conclusion: Among hospitalized COVID19 patients, hydroxychloroquine alone cannot reduce the mortality rate, but the combined use of hydroxychloroquine and azithromycin can significantly increase the mortality rate
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Among hospitalized COVID19 patients, the use of hydroxychloroquine alone does not reduce the mortality rate, but the combined use of hydroxychloroquine and azithromycin can significantly increase the mortality rate
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Original source

 Fiolet T, Guihur A, Rebeaud ME,Effect of hydroxychloroquine with or without azithromycin on the mortality of coronavirus disease 2019 (COVID-19) patients: a systematic review and meta-analysis.

 Effect of hydroxychloroquine with or without azithromycin on the mortality of coronavirus disease 2019 (COVID-19) patients: a systematic review and meta-analysis.
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