Colchicine is a first-line medication for gout patients, but it is in mortal danger, and it is necessary to be cautious when taking the drug!

When it comes to colchicine, gout with hyperuric acid is certainly not unfamiliar

When gout attacks, acute gout arthritis is the most common first symptom of gout, and the corresponding traditional treatment drugs include colchicine

Although the effect of colchicine is good, and the price is still low, but because the therapeutic dose of colchicine is very close to the poisoning dose, there are some adverse reactions, and even colchicine poisoning incidents have occurred!

Colchicine poisoning incident

It is said that a postdoctoral fellow from a famous university was introduced to the teaching and research department of a university as a director

This post-doctor who had a systemic organ injury during poisoning and had survived more than 40 days in the intensive care unit was that he could not die, one of the reasons why he had a habit of drinking only a small sip of a drink each time, so the dose of poisoning was relatively small; The second is that colchicine is a strong metabolic substance, which is rapidly metabolized and causes the body to quickly discharge the agent, thus retrieving a life

Therefore, when taking colchicine, we must follow the doctor's advice and take

1What are the side effects of colchicine?

1 gastrointestinal reaction

Gastrointestinal reactions are the main side effects of colchicine in the early stages, manifested by nausea, vomiting, abdominal pain, diarrhea, loss of appetite, etc

2 Hematologic reactions

Colchicine has a bone marrow suppression effect and can lead to thrombocytopenia, neutropenia, and even aplastic anemia

3 nervous system

Peripheral axonal polyneuropathy can occur and present as numbness, tingling, and weakness

4 other rare side effects

Including hair loss, rash, fever, liver damage, deformities, etc

2Can colchicine also be used as a medicine to treat gout?

First of all, we need to know how colchicine works:

On the one hand, colchicine can bind the main components of intracellular microtubules, tubulin, prevent microtubule polymerization, inhibit spindle formation, prevent cell mitosis, reduce cell necrosis, weaken neutrophil activity (do not let it swallow uric acid again), inhibit various inflammatory factors such as prostaglandins, leukotriene, interleukin-6, etc.

On the other hand, colchicine not only has side effects, but also is cytotoxic

At present, the clinical poisoning treatment for colchicine usually uses conventional methods such as gastric lavage and vomiting, and there is no specific antidote, which greatly limits the clinical application

Clinicians often stop the drug according to the patient's symptoms of side effects such as vomiting and diarrhea, that is, the maximum dose is used, and it is difficult to grasp the scale

Even so, colchicine is still the drug of choice for acute attacks of gout, mainly because there is no drug that can control the pain

3What should I pay attention to when taking colchicine?

Colchicine has outstanding advantages, disadvantages are also obvious, the use should pay attention to the following points:

1.

2.

3.
The detoxification ability decreases when liver function insufficiency decreases, which will aggravate liver toxicity;

4.
Long-term application can cause inhibition of bone marrow hematopoietic function, such as decreased granulocyte and platelet counts, aplastic anemia, etc.
, and can also cause myositis and peripheral neuropathy, the latter is often difficult to recover, at present, it is not advocated as a drug for long-term prevention of gouty arthritis attacks;

5.
During the acute gout period, each course of treatment should be discontinued for 3 days to avoid accumulation poisoning;

6.
The dose of the elderly over 70 years old should be reduced
.

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