Colorectal cancer genetic testing allows doctors to accurately determine the status of tumor patients.

Due to the westernization of diet and other reasons, in recent years, the domestic colorectal cancer is increasingly high, Guangzhou alone, more than 1000 people die of the disease each year.
recently at an academic conference on colorectal cancer, domestic bowel cancer experts said that "precision medicine" model has arrived, recommended that patients with a family adenoma polyps, digestive system or urinary system tumor history of early genetic testing related to colorectal cancer, so that doctors can make accurate judgments, guide prevention and treatment.
, driven by technological innovations such as targeted therapy, the survival of cancer patients has been extending, and some cancers have grown from only a few months to a few years today.
however, many treatments are not effective for all patients.
According to the U.S. Food and Drug Administration (FDA), cancer drug treatments, such as chemotherapy, are on average only 20 percent efficient, meaning that 80 percent of patients are ineffective and have many adverse reactions.
recently, the Colorectal Cancer Summit Forum and the 16th Guangdong Provincial Colorectal Cancer Conference were held in Guangzhou. During the
meeting, Professor Wandson, chief expert of colorectal cancer at Sun Yat-sen University Cancer Prevention Center and honorary director of the China Anti-Cancer Association's Colorectal Cancer Professional Committee, said that colorectal cancer also has the following conditions, such as some families have many people with adenoma polyps, patients in their teens with stool with mucus, blood symptoms, 20 years of age began to change cancer, 50 years old died of colorectal cancer.
20% to 25% of colorectal cancers will occur in early metastasis, and eventually 40% to 50% of patients will die.
, do patients who discover early lesions need to have their entire intestines removed in advance to prevent cancer? Be aware that this requires artificial anus creation and the patient's quality of life is poor.
therefore, doctors need to make accurate judgments to avoid mistakes.
to solve this problem, the "precision medicine" model came into being, looking for target genes for cancer cells at the molecular level. large-scale medical epidemiology survey in developed countries such as the United States and Britain
through big data to find out a lot of tumor target genes, there are more than 20 colorectal cancer, 4 of which are more commonly used in clinical. Dr. Lu Zhenhai, deputy director of colorectal medicine at Sun Yat-sen University Cancer Hospital in
, said 20 percent of colorectal cancer patients show editability, and testing their genes can be used for colorectal cancer screening prevention, as well as guiding the treatment of patients with advanced stages.
Wandelson said that by testing the target gene expression indicators of four colorectal cancers, doctors can determine whether there is a need for some kind of treatment, to be targeted.
for example, a patient with a target gene mutation can not use a drug, but with bad results, for example, some patients cancer recurrence, cancer cells after the last treatment of the impact of genetic mutations, and some patients' cancer primary and metastatic cancer cell genes are different - these conditions with the same drug treatment will be very poor, so the need for genetic testing.
he also said the results of genetic testing could also predict how long a patient will survive.
genetic testing, specifically blood tests and a biopsy of tumor tissue with a colonoscopy, the cost ranges from thousands to tens of thousands of dollars, depending on the number of target genes, has not yet been widely available.
, Vanderson suggests that patients with familial adenoma polyps are tested at the age of 18, but some adult patients are unaware of the stakes and are reluctant to test.
in addition, people with endometriosis, stomach cancer, digestive or urinary system tumors should also pay attention to the risk of colorectal cancer, it is best to do genetic testing.
Source: Decoding Medicine.