Combined drug use can increase life expectancy and nearly double!

Extended life test seisi-turned-! A team of researchers led by Dr. Jan Gruber of the Yale-NUS University have found a combination of drugs that not only prolongs the healthy life of the hidden nematode, but also slows its aging rate, or means longer and healthier lifein in the future.
study, published in the journal "Drug Synergy Slows And Improves Health through IGF and SREBP Signaling", provides an important basis for further research into the design of drug combinations that have the same effect on mammals. "Many countries around the world, including Singapore, face problems related to an ageing population," said
Jan Gruber.
If we can find ways to prolong healthy life expectancy and slow population ageing, we can offset the adverse effects of population ageing, which not only provides medical and economic benefits for countries, but also provides a better quality of life for their people."
"Gruber team wanted to explore how long it can be extended to healthy life by combining drugs that target several possible biological pathways that affect life expectancy.
, for example, rapamycin, a drug administered after an organ transplant to prevent the body's immune system from rejecting transplanted organs, has been shown to extend the life span of many organisms, including nematodes, fruit flies and mice.
. New achievements in animal longevity experiments, Gruber and his team applied two or three compounds to the beautiful hidden nematodes.
results showed that the use of a combination of two drugs extended the life expectancy of the sly hidden nematodes, which exceeded the effect of each drug being used alone, and that the combination with the third compound almost doubled the life expectancy of the snubne nematode.
this effect is greater than any previous intervention to treat adult animals to extend their life.
on the other hand, the drug treatment has no adverse effects on the health of the sly nematode.
researchers also found that the treated sly nematodes were healthier at all ages, and that a greater proportion of them were in good health over their extended life spans.
this is an important point for future potential human aging interventions, as longer healthy life expectancy, not just longer, will bring significant medical and economic benefits. "Not only do we benefit from longevity, but we also benefit from age-related diseases such as arthritis, cardiovascular disease, cancer or Alzheimer's disease," says Dr.
Gruber.
these diseases currently require very expensive treatment, the economic benefits of long-term health will undoubtedly be enormous.
", he also cites a 2017 study that found that the U.S. government would save $7.1 trillion in public health costs over the next 50 years if the aging rate of U.S. citizens fell by 20 percent.
. Future Human Longevity Drug Research Strategy In this study, Gruber's lab collaborated with Nicholas Tolwinski of Yale-NUS, who found that a fruit fly (Drosophila melanogaster) had experienced significant longer life after being treated with a similar combination of drugs.
the similar life extensions experienced by these two evolutionaryly distinct organisms suggest that the biological mechanisms that regulate the interactions of these drugs during the aging process are ancient, making similar interactions between aging pathways more likely to be targeted in humans. Dr.
Gruber believes the study is a theoretical validation that suggests that drug interventions for multiple aging pathways are promising strategies to slow aging and significantly prolong the healthy life of adult animals.
the next step in the study will be to focus on three areas.
first, expand this approach to design interventions that are more effective than this study; second, determine how drugs interact with the molecular and biological mechanisms that delay aging and extend life in order to develop computer models that simulate these interactions and allow researchers to test more combinations through computer modeling; and the ultimate goal of this series of studies will be to develop drug interventions that are sufficiently safe for the human body.
Source: Biological Exploration.