Common sample cocrystalline temperature and freeze-dried method.
Last Update: 2020-10-19
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s vacuum freezing
technology, referred to as freeze-dried technology, is one of the common applications used in biology and other fields to extract purification and preservation of samples, this paper will list some common substances cocrystalline temperature and its freeze-drying methods, and discuss with you.
It is well known that the most critical condition in the freeze-drying process is to control the sample temperature to stay below the cocrystalline temperature by 10-15 degrees C, so as to ensure that the sample does not melt, to maintain the micro-porous structure and chemical and chemical properties remain intact. Some common samples of cocrystalline point temperature data and freeze-dried methods are sorted out for your reference.
as can be seen from the table above, the cocrystalline temperature of most samples is above -40, which is why the vast majority of
manufacturers have cold trap temperature between -50 to -55 degrees C model reasons, with this section of the cold trap temperature is sufficient to meet the freeze-dried experimental requirements of most experimental samples. Table 2 lists some common sample freeze-drying methods recommended, including prefrost temperature, the vacuum value that the system should maintain when freeze-drying, the way of freeze-dried Process A or Process B, the choice of freeze-dried containers, the functional requirements of the freeze-drying machine, etc.
Note: Process A: Prefrozen, drying are carried out in a cold trap, Process B: Prefreeze is carried out in other instruments, such as
ultra-low temperature refrigerator
, cold water bath, etc., drying in a freeze-drying machine, such as in the drying chamber of acrylic glass
The actual cocrystalline temperature is slightly different, and if the cocrystalline temperature needs to be accurately understood, special instruments are required to measure it, such as the cocrystalline test device provided by Martin Christ of Germany, including temperature, crystal unit resistance integration sample probe, which can directly detect the effect of different temperature changes on the crystal structure, resulting in a continuous and accurate cocrystalline test curve. Sample temperature is a very important parameter in monitoring the freeze-drying process, the traditional wired sample temperature sensor due to wire interference, operation will cause some problems, Martin Christ designed wireless temperature sensor is an innovative creation, the process optimization is very meaningful..
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