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Commonly used drugs for hyperlipidemia, all in one go!

 Last Update: 2021-09-11
 Source: Internet
 Author: User

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（TC）、（LDL-C）、（TG）（VLDL），LDL-C，HDL-C
。

At present, comprehensive treatment is the main treatment , among which lifestyle intervention is the primary basic treatment measure.

Drug treatment is easy to accept and has a positive effect.
Pay attention to strict control of indications.
Plasma purification therapy or surgical treatment is a supplement to drug therapy.
Gene therapy is still being explored.
In

Comprehensive therapy, lifestyle intervention, drug therapy, plasma purification therapy, surgical therapy, gene therapy

HMG-CoA reductase inhibitors (statins)

Main indications

mechanism

Common side effects

Representative drug

Representative drug	Starting dose	Maximum dose
Lovastatin	20-40mg, qd	80mg, qd
Pravastatin	40-80mg, qd	80mg, qd
Simvastatin	20-40mg, qd	80mg, qd
Fluvastatin	20-40mg, qd	80mg, qd
Atorvastatin	20-40mg, qd	80mg, qd
Rosuvastatin	5-20mg, qd	40mg, qd
Pitavastatin	1-2mg, qd	4mg, qd

Representative drug

Starting dose

Maximum dose

Lovastatin

20-40mg, qd

80mg, qd

Pravastatin

40-80mg, qd

80mg, qd

Simvastatin

20-40mg, qd

80mg, qd

Fluvastatin

20-40mg, qd

80mg, qd

Atorvastatin

20-40mg, qd

80mg, qd

Rosuvastatin

5-20mg, qd

40mg, qd

Pitavastatin

1-2mg, qd

4mg, qd

Representative drug

Starting dose

Maximum dose

Representative drug

Starting dose

Maximum dose

Lovastatin

20-40mg, qd

80mg, qd

Lovastatin

20-40mg, qd

80mg, qd

Pravastatin

40-80mg, qd

80mg, qd

Pravastatin

40-80mg, qd

80mg, qd

Simvastatin

20-40mg, qd

80mg, qd

Simvastatin

20-40mg, qd

80mg, qd

Fluvastatin

20-40mg, qd

80mg, qd

Fluvastatin

20-40mg, qd

80mg, qd

Atorvastatin

20-40mg, qd

80mg, qd

Atorvastatin

20-40mg, qd

80mg, qd

Rosuvastatin

5-20mg, qd

40mg, qd

Rosuvastatin

5-20mg, qd

40mg, qd

Pitavastatin

1-2mg, qd

4mg, qd

Pitavastatin

1-2mg, qd

4mg, qd

Note: qd, once a day

Main indications

mechanism

Common side effects

Representative drug

Main indications

mechanism

Common side effects

4.
Representative drugs :

Representative drug

Representative drug	Starting dose	Maximum dose
Cholestyramine	4g, qd	32g, qd
Colestipol	5g, qd	40g, qd
Kollivellen	3750mg, qd	4375mg, qd

Representative drug

Starting dose

Maximum dose

Cholestyramine

4g, qd

32g, qd

Colestipol

5g, qd

40g, qd

Kollivellen

3750mg, qd

4375mg, qd

Representative drug

Starting dose

Maximum dose

Representative drug

Starting dose

Maximum dose

Cholestyramine

4g, qd

32g, qd

Cholestyramine

4g, qd

32g, qd

Colestipol

5g, qd

40g, qd

Colestipol

5g, qd

40g, qd

Kollivellen

3750mg, qd

4375mg, qd

Kollivellen

3750mg, qd

4375mg, qd

Note: qd, once a day

Four, MPT inhibitor

Four, MPT inhibitor Four, MPT inhibitor

1.
Main indication : Homozygous familial hypercholesterolemia (HoFH)

Main indications

2.
Mechanism : Reduce VLDL synthesis

mechanism

3.
Common side effects : skin flushing, diarrhea, increase liver fat

Common side effects

4.
Representative drug : Lometapide mesylate, starting dose: 5mg, qd, maximum dose: 60mg, qd
.

Representative drug

Five, ApoB inhibitor

Five, ApoB inhibitors Five, ApoB inhibitors

1.
Main indication : Homozygous familial hypercholesterolemia (HoFH)

Main indications

2.
Mechanism : Reduce VLDL synthesis

mechanism

3.
Common side effects : injection site reflection, flu-like symptoms, increase liver fat

Common side effects

4.
Representative drug : Mipomethacin, starting dose: 200mg, subcutaneous injection (SC), qw, maximum dose: 200mg, SC, qw
.

Representative drug

Six, niacin

Six, niacin six niacin

1.
Main indications : elevated LDL-C, elevated TG

Main indications

2.
Mechanism : Reduce VLDL synthesis

mechanism

3.
Common side effects : skin flushing, gastrointestinal discomfort, elevated blood sugar, elevated blood uric acid, and impaired liver function

Common side effects

4.
Representative drugs :

Representative drug

Representative drug	Starting dose	Maximum dose
Quick release	100mg, tid	1g, tid
Sustained release	250mg, bid	1. 5g, bid
Extended release	500mg, qn	2g, qn

Representative drug

Starting dose

Maximum dose

Quick release

100mg, tid

1g, tid

Sustained release

250mg, bid

1.
5g, bid

Extended release

500mg, qn

2g, qn

Representative drug

Starting dose

Maximum dose

Representative drug

Starting dose

Maximum dose

Quick release

100mg, tid

1g, tid

Quick release

100mg, tid

1g, tid

Sustained release

250mg, bid

1.
5g, bid

Sustained release

250mg, bid

1.
5g, bid

Extended release

500mg, qn

2g, qn

Extended release

500mg, qn

2g, qn

Note: tid, three times a day, bid, twice a day, qn, before going to bed

Seven, fibric acid derivatives

Seven, fibric acid derivatives Seven, fibric acid derivatives

1.
Main indications : elevated TG

Main indications

2.
Mechanism : reduce VLDL synthesis and increase lipoprotein lipase levels

mechanism

3.
Common side effects : digestive bad, myalgia, gallstones, elevated transaminase

Common side effects of digestion

4.
Representative drugs :

Representative drug

Representative drug	Starting dose	Maximum dose
Gemfibezi	600mg, bid	600mg, bid
Fenofibrate	145mg, qd	145mg, qd

Representative drug

Starting dose

Maximum dose

Gemfibezi

600mg, bid

Fenofibrate

145mg, qd

Representative drug

Starting dose

Maximum dose

Representative drug

Starting dose

Maximum dose

Gemfibezi

600mg, bid

Gemfibezi

600mg, bid

Fenofibrate

145mg, qd

Fenofibrate

145mg, qd

Note: qd, once a day, bid, twice a day

8.
Omega -3 fatty acids

Eight, eight, ω ω -3 fatty acids -3 fatty acids

1.
Main indications : elevated TG

Main indications

2.
Mechanism : Increase TG catabolism

mechanism

3.
Common side effects : indigestion, fishy breath smell

Common side effects

4.
Representative drugs :

Representative drug

Representative drug	Starting dose	Maximum dose
Ethyl Omega-3 Acid	4g, qd	4g, qd
Eicosapentaenoate	4g, qd	4g, qd

Representative drug

Starting dose

Maximum dose

Ethyl Omega-3 Acid

4g, qd

Eicosapentaenoate

4g, qd

Representative drug

Starting dose

Maximum dose

Representative drug

Starting dose

Maximum dose

Ethyl Omega-3 Acid

4g, qd

Ethyl Omega-3 Acid

4g, qd

Eicosapentaenoate

4g, qd

Eicosapentaenoate

4g, qd

Note: qd, once a day

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