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This article is from the NEJM Journal Watch Long-Term Survival Outcomes Support Laparoscopic Distal Gastrectomy for Gastric Cancer.
There was no significant difference in the 5-year overall survival rate between patients randomly assigned to undergo laparoscopic and open distal gastrectomy
.
In the treatment of gastric cancer, the application of laparoscopic gastrectomy is increasing worldwide, because clinical trials have shown that compared with open gastrectomy, laparoscopic gastrectomy has the same oncological outcome and is For early and locally advanced gastric cancer, laparoscopic gastrectomy may reduce surgical complications
.
Chinese researchers published the 5-year survival rate results of the CLASS-01 trial this time
.
The trial randomly assigned 1,056 patients with locally advanced gastric cancer to undergo open or laparoscopic distal gastrectomy combined with D2 lymph node dissection
.
The average age of the two groups (57-56 years), pathological stage (stage II, 26%-27%; stage III, 42%-43%; N0, 41%-42%) and the status of receiving adjuvant chemotherapy (37%) ~42%) are similar
.
The 5-year overall survival rates of the laparoscopic distal gastrectomy group and the open distal gastrectomy group were similar (72.
6% and 76.
3%; hazard ratio, 1.
17; P=0.
19)
.
There was also no significant difference in the risk of gastric cancer-related death between the two groups (hazard ratio, 1.
14; P=0.
34)
.
In the analysis of survival outcomes based on cancer stages, there was no significant difference between the two groups
.
Comment on growing evidence that continues to support laparoscopic gastrectomy combined with D2 lymph node dissection for early and locally advanced gastric cancer
.
This surgical method is still not fully used in Western countries
.
The reviewed article Huang C et al.
Laparoscopic vs open distal gastrectomy for locally advanced gastric cancer: Five-year outcomes from the CLASS-01 randomized clinical trial.
JAMA Surg 2021 Oct 20; [e-pub].
(https://doi .
org/10.
1001/jamasurg.
2021.
5104) Related reading NEJM Journal Watch The NEJM Journal Watch is published by the NEJM Group.
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Copyright information This article was translated, written or commissioned by the "NEJM Frontiers of Medicine" jointly created by the Jiahui Medical Research and Education Group (J-Med) and the "New England Journal of Medicine" (NEJM)
.
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