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    Home > Food News > Food Articles > Conference report-Professor Meng Xiangchen-Characteristics of the intestinal flora of breastfed infants and the interventional effect of bifidobacteria on the intestinal barrier

    Conference report-Professor Meng Xiangchen-Characteristics of the intestinal flora of breastfed infants and the interventional effect of bifidobacteria on the intestinal barrier

    • Last Update: 2021-11-11
    • Source: Internet
    • Author: User
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    Professor Xiangchen Meng

    Key Laboratory of Dairy Science, Ministry of Education, School of Food Science, Northeast Agricultural University

    Meng Xiangchen, professor, doctoral supervisor, leader of the secondary discipline of food fermentation engineering, head of the dairy microbiology and biotechnology platform of the Key Laboratory of Dairy Science of the Ministry of Education
    Visiting scholar at the University of Cork (UCC) in Ireland, senior visiting scholar at Utah State University in the United States

    Standing director of China Animal Products Processing Research Association, food safety expert of State Food and Drug Administration, director of China Dairy Association, member of Agricultural Products Processing Standardization Technical Committee of Ministry of Agriculture and Rural Affairs, editorial board of "China Brewing" and "Dairy Science and Technology" magazine; International; , Reviewers of dozens of domestic academic journals

    The winner of the Young Science and Technology Award of the Chinese Agricultural Society, and the winner of the Outstanding Young Teacher Award of the Luo Chengyu Fund of the Animal Products Processing Research Association

    Mainly engaged in teaching and scientific research in the fields of dairy science and technology, food microbiology and biotechnology, and food fermentation

    He has presided over and participated in the National Natural Science Foundation of China, the Innovation Team of the Ministry of Education, the "863" Project, the National Science and Technology Support Plan, and more than 20 projects of various provinces and cities, and won 8 awards at all levels

    More than 10 authorized patents have been granted and 3 scientific and technological achievements have been transferred

    He has published more than 10 monographs and textbooks, and published more than 200 academic papers, of which more than 50 are collected by SCI and EI



    The characteristics of the intestinal flora of breast-fed infants and the effect of bifidobacteria on the intestinal barrier intervention


    Infancy is a critical period for colonization of intestinal flora.
    The early colonization mode of flora directly affects the intestinal barrier function and immune system development of infants during their growth

    Therefore, we chose the key stage of infancy to analyze the characteristics of the intestinal flora of breastfed infants, explore the relationship between the composition of breast milk and the intestinal flora of infants, and perform whole-genome sequencing and bioinformatics analysis of bifidobacteria from the infant’s intestinal tract In addition, the effect and mechanism of the intervention of two surface proteins of bifidobacteria on the intestinal barrier were explored

    The results showed that the oligosaccharide components in breast milk are beneficial to shape the intestinal flora of infants, mainly bifidobacteria.
    About 11% of the coding genes of bifidobacteria isolated from the intestinal tract of breastfed infants are involved in carbohydrate transport and metabolism.
    Helps bifidobacteria to use oligosaccharides in breast milk

    Bifidobacterium surface protein GroEL and transaldolase can regulate the expression of tight junction related proteins through NF-κB, MAPK, Rho and MLCK signaling pathways, effectively preventing endotoxin-induced inflammation of intestinal epithelial cells


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