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    Home > Congratulate! Lin Guoqiang's new book chiral synthesis: basic research and progress will be published this month

    Congratulate! Lin Guoqiang's new book chiral synthesis: basic research and progress will be published this month

    • Last Update: 2018-01-10
    • Source: Internet
    • Author: User
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    In the long process of chemical evolution, numerous chiral compounds have appeared on the earth Most of the organic molecules that make up life are chiral molecules, either in species or in quantity Life systems have very strong chiral recognition ability, and stereoisomers of different configurations often show very different physiological efficiency ——Academician Zhou Weishan's left-handed and right-handed conch shells come from Wikipedia's "thalidomide" event, also known as the "reaction stop event" In the 1960s, there was a great stir in the western world Thalidomide, which was widely used as an anti pregnancy drug at that time, was actually a pair of chiral molecules, in which the right-hand (R-configuration) molecule had the activity of inhibiting pregnancy reaction, while the left-hand (s-configuration) molecule had teratogenicity to the fetus Since then, the research of chiral drugs has attracted more and more attention, and has become a hot topic in the field of medicine The simplest way to obtain a single stereoisomer is chiral synthesis Chiral synthesis, also known as asymmetric synthesis, aims to maximize the molecular yield of the target stereoconfiguration through asymmetric synthesis environment Chiral synthetic chemistry plays an important role in the research of chiral drugs The construction of chiral molecules, such as pesticides and polymers, needs the support of this tool It is a compulsory course for relevant researchers to quickly understand and master this tool For students and practitioners who are interested in learning, they also need systematic learning materials Chiral synthesis methodology has developed rapidly for 20 to 30 years, and it is still the research hotspot and frontier in the field of organic chemistry until now It is not an easy thing whether "new people" want to "get started" or "Acquaintances" want to "explore" In this case, a "shovel" is needed to help learners "dig through the door", not only to teach basic knowledge, but also to show cutting-edge breakthroughs The 2017 project "chiral synthesis: basic research and progress", jointly written by academician Lin Guoqiang, Professor Sun Xingwen and researcher Hong ran, is such a "shovel" The cover of "chiral synthesis: basic research and progress" systematically and comprehensively introduces the basic research and progress of chiral synthesis, keeping pace with the latest achievements In the book, modules are divided according to functional group reaction categories, covering asymmetric alkylation substitution, conjugation and enantioselective nucleophilic addition of carbonyl compounds, aldol condensation, Allylation and asymmetric cyclization, asymmetric oxidation and functional group reaction of olefins, asymmetric catalytic hydrogenation The application of asymmetric reaction methodology in the synthesis of natural products and biocatalytic chiral synthesis were also reviewed In addition, other types of asymmetric reactions, named reactions and the recovery and reuse of catalysts for asymmetric reactions are briefly described in the book, and metal ligands, organic small molecules and ion pairs in recent years are listed The latest progress in catalytic asymmetric reactions is highlighted The advantages of various asymmetric synthesis approaches, the development space worthy of attention and the different reaction methods are discussed It is worth mentioning that this book also lists a representative review, which is convenient for readers to consult Combining the basic knowledge with the latest progress, and equipped with all kinds of intimate details, readers have a feeling that they can "dig a well" with it No matter the senior undergraduates and postgraduates of organic chemistry, pharmaceutical chemistry and fine chemical industry, or the teachers and researchers of universities and scientific research institutes, pharmaceutical research and development, fine organic chemical industry and technical personnel of related industries, they can open the book for good Introduction of academician Lin Guoqiang: Lin Guoqiang, researcher, organic chemist In 1968, he graduated from Shanghai Institute of organic chemistry, Chinese Academy of Sciences and studied under Professor Zhou Weishan In the same year, I have worked in the Institute till now He was a visiting scholar at the Royal Swedish Institute of technology from 1981 to 1982 From 1986 to 1987, he went to the University of Pittsburgh and the Department of research and development of Scheck pharmaceutical industry as a visiting scientist Promoted to researcher in 1991 1990-1999 deputy director and director of Shanghai Institute of organic chemistry, Chinese Academy of Sciences He was elected academician of the Chinese Academy of Sciences in 2001 From 2006 to 2014, he concurrently served as the director of the chemical science department of the National Natural Science Foundation of China Research direction: the research fields include the structure and synthesis of natural products with physiological activity, asymmetric synthesis reaction, biocatalysis reaction and the synthesis of small molecules of chiral drugs, etc Focusing on the chirality basis and related scientific issues, systematic research has been carried out in the fields of identification and synthesis of insect pheromones, biocatalysis, synthesis of natural products and asymmetric reactions, with distinctive and influential research results At present, it is mainly engaged in the study of the reactions of chiral high allylamine and chiral diene ligands, which show excellent reactivity and enantioselectivity in asymmetric reactions The new diene ligands were commercialized by sigma Aldrich and included in Wiley, the organic synthesis reagent Awards and honors: in 1987 and 2013, he won the second prize of national science and Technology Progress Award and the first prize of science and technology progress award of Chinese Academy of Sciences (1986); in 1992, he was awarded the national level expert with outstanding contributions; in 1996, he was awarded the honorary title of excellent graduate tutor of Chinese Academy of Sciences; in 2006, he Liang and he lijijin science and Technology Progress Award and Shanghai Science and education Party committee system Excellent Communist Party member; In 2008, he was awarded the honorary title of "outstanding contribution teacher" by Graduate School of Chinese Academy of Sciences; in 2012, he was awarded the fifth national excellent science and technology worker; in 2013, he was awarded the China Industry University Research Cooperation Innovation Award; in 2014, Chen Jiageng Chemical Science Award; in 2014, the first prize of Shanghai Natural Science Award and the "chiral chemistry Achievement Award" by Chinese Chemical Society; From 2010 to 2014, he was awarded the title of advanced worker in Shanghai, and won the second prize of National Natural Science in 2016 Representative works: he has published more than 245 academic papers, authorized 40 Chinese patents, 1 American patent, 3 PCTs, and 10 implementation transfers, of which 2 won the third prize of Shanghai invention and creation patent award and the 16th China Patent Gold Award He has written many academic works at home and abroad: principle and application of asymmetric synthesis, chiral drugs research and evaluation, and chemical and biological action.
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