Contribution of CE to the Analysis of Protein or Peptide Biomarkers
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Last Update: 2020-12-04
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Source: Internet
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Author: User
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Biomarker analysis is pivotal for disease diagnosis and one important class of biomarkers is constituted by proteins and peptides. This review focuses on protein and peptide analyses from biological fluids performed by capillary electrophoresis. The variousstrategies that have been reported to prevent difficulties due to the handling of real samples are described. Innovative techniquesto overcome the complexity of the sample, to prevent the adsorption of the analytes on the inner capillary wall, and to increasethe sensibility of the analysis are summarized and illustrated by different applications. To fully illustrate the contributionof CE to the analysis of biomarkers from human sample, two detailed protocols are given: the analysis from CSF of five amyloidpeptide, biomarkers of the Alzheimer disease, and the analysis of sialoforms of transferrin from human serum.
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