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On June 15, 2021, RayzeBio announced the completion of a Series C financing of US$108 million to further advance its pipeline of targeted radiopharmaceuticals for cancer treatment
.
By coupling radioisotopes with drugs that specifically bind to tumor surface proteins, targeted radiotherapy that delivers radioactive compounds into tumors is attracting high attention
.
Previously at the ASCO annual meeting, Novartis' 177Lu-PSMA-617 therapy reduced the risk of death in prostate cancer patients by 38% in a phase 3 clinical trial
RayzeBio focuses on the development of powerful radioactive targeted therapies for solid tumor targets that have been clinically validated
.
The macrocycle peptide-mimetics developed by the company has similar affinity and specificity as antibodies, and can specifically bind to the target on the tumor; at the same time, it has similar characteristics as small molecule drugs and can penetrate the tumor deeply.
And rapid and effective synthesis, is an effective carrier for targeted delivery of radiopharmaceuticals
The isotope actinium-225 used by the company is an isotope that releases alpha particles
.
The distance for alpha particles to act in tissues is very short, only a few cells wide
"Targeted radiopharmaceuticals represent a highly clinically validated treatment model
.
" said Dr.
Ken Song, RayzeBio's president and CEO.
The lead investor in C round of financing by the Venrock Healthcare Capital Partners, new investors, including Perceptive Advisors, capital Vivo (Vivo Capital), Acuta Capital Partners , Deerfield Management and the X-TCG
.
Also participating in the investment are existing investors in RayzeBio