Crack the mystery of the cell origin of microglial rejurepopulation in the brain.

Recently, the Team of Peng Bo of the Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences, in collaboration with Dr. Rao Yanxia of the University of Hong Kong and Professor Yuan Yufei of Shanghai Mental Health Center, for the first time overturned the previous conclusion that rejuveitous small glial cells originated from Nestin-positive precursor cell differentiation, and found that their rejuvevative cells originated entirely from the proliferation of residual glial cells.
research in the journal Nature-Neuroscience, entitled "Repered microglia are solelyllyed from the thesaire residual of microglia after acute."
the ability to regenerate the central nervous system of adult mammals, including the brain, retina and spinal cord, is extremely limited, and it has been thought for a considerable period of time that damage to the central nervous system will not be repaired.
2014, researchers at the University of California, Irvine, discovered cell regeneration in the brains of mice, finding that small glial cells in the brain can almost completely kill small glial cells (99%) in the brain by specifically inhibiting the colony-stimulating factor 1 receptor (CSF1R) and that new glial cells in the brain occur after a short recovery period.
these regenerative small glial cells can quickly be bred into the whole brain and fully restored to their original state (e.g. density, distribution, and morphology) in about a week.
this is the first large-scale cell regeneration in the central nervous system of an adult mammal, a process known as "small glial cell regeneration."
the University of California team speculated through histological immunostaining that the rebreeding cells may have been differentiated by a class of cells in the brain that instantaneously express nestin.
is thought to be the third type of stem cells found in the central nervous system of adult mammals, in addition to neural stem cells and progest cells of protrusion cells.
's conclusions have been widely concerned and controversial.
in the study, The Pembroke team, through a variety of genealogy tracking techniques, overturned the conclusion that rebreeding small glial cells originated from Nestin-positive precursor cell differentiation, and found that their rebreeding cells originated entirely from the self-proliferation of small glial cells with less than 1% remaining in the brain.
the phenomenon is the fastest cell proliferation ever found in the central nervous system of adult mammals. in addition,
, the Penb team also explained the possible mechanism of cell reproduction through single-cell RNA sequencing, and through whole-brain RNA sequencing, found a high functional similarity between rebreeding small glial cells and primary small glial cells.
the study successfully solved the mystery of the cell origin of microglial rejures in the brain, put an end to the major controversy over the presence of small glial cell precursor cells in the central nervous system of adult mammals, and has great scientific value for the research of central nervous system regeneration and the steady state maintenance of small glial cells.
Huang Yubin and Xu Wei, postdoctoral fellow of The Peng Bo team, are the co-first authors of the paper.
the research has been supported by the National Key Research and Development Program, the National Natural Science Foundation, the Shenzhen Knowledge Innovation Program, the Guangdong Innovation Team and the Shenzhen Peacock Team.
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