Crit Care: Accuracy of Heparin Binding Protein in Diagnosing Nosocomial Meningitis and Ventriculitis

Sensitive and accurate diagnosis of nosocomial meningitis and ventriculitis remains a key issue
.

Recently, a research article was published in Critical Care, an authoritative journal in the field of critical care medicine, to investigate the effect of cerebrospinal fluid heparin-binding protein (HBP) compared with procalcitonin and lactate in hospital-acquired meningitis and ventriculitis.
diagnostic value
.

In this observational study, we included 323 suspected patients, 42 of whom were excluded because they could not be accurately grouped, 131 subjects who were eventually diagnosed with nosocomial meningitis or ventriculitis and 131 who were ultimately diagnosed with infection .
150 patients were included in the study
.

The area under the receiver operating characteristic curve was maximal at 0.
99 (95% confidence interval, 0.
98-1.
00) for HBP, 0.
98 (95% confidence interval, 0.
96-0.
99) for lactate, and 0.
69 for procalcitonin (95% confidence interval, 0.
96-0.
99).
0.
62-0.
75)
.

It can be seen that HBP in cerebrospinal fluid is a reliable auxiliary diagnostic marker, which is superior to lactate and procalcitonin in differentiating nosocomial meningitis and ventriculitis, and also helps to solve the diagnostic difficulties caused by empirical antibiotic
therapy .

Original source:

Yueyue Kong.
et al.
Accuracy of heparin-binding protein for the diagnosis of nosocomial meningitis and ventriculitis .
Critical Care.
2022.
https://ccforum.
biomedcentral.
com/articles/10.
1186/s13054-022-03929-x

It can be seen that HBP in cerebrospinal fluid is a reliable auxiliary diagnostic marker, which is superior to lactate and procalcitonin in differentiating nosocomial meningitis and ventriculitis, and also helps to solve the diagnostic difficulties caused by empirical antibiotic
therapy .

Original source:

Yueyue Kong.
et al.
Accuracy of heparin-binding protein for the diagnosis of nosocomial meningitis and ventriculitis .
Critical Care.
2022.
https://ccforum.
biomedcentral.
com/articles/10.
1186/s13054-022-03929-x

It can be seen that HBP in cerebrospinal fluid is a reliable auxiliary diagnostic marker, which is superior to lactate and procalcitonin in differentiating nosocomial meningitis and ventriculitis, and also helps to solve the diagnostic difficulties caused by empirical antibiotic
therapy .

Original source:

Yueyue Kong.