Crit Care: Effects of pathogens and infected lesions on the calcin valueofof bacterial emisor or Candida in patients with sepsis

The purpose of this study is to evaluate the accuracy of the diagnosis of Gram-negative mycoplasma at serum concentration of Type C globulin (PCT) and the correlation of PCT serum concentration seroconcentration stoicism with more specific pathogens and infectious lesionsa secondary analysis of a prospective patient-level dataset collected in a cluster random quality improvement trialThe trial included sepsis patients with organ dysfunction treated in the intensive care unit involved in the trial between 2011 and 2015The experimental performance of predicting Gramnegative mystemia was evaluated by the receiver operating curve analysisThe independent effects of specific pathogen groups and infection lesions on PCT concentrations were assessed through a linear logistic regression modelblood culture (BC) and PCT concentration tests were conducted in 4,858 of the 6,561 patients recordedThe results showed that the PCT was significantly higher than Gram-positive myomia sepsis or Candidaemia (P 0.001) compared to Gram-negative or CandiduticemiaCompared to all other blood culture results (including negative blood culture), the area under the curve of the predicted Gram-negative mycomosis is 0.72 (95% confidence interval is 0.71-0.74)The optimized truncation value is 10 ng/ml (sensitivity 69%, 35% specific)There are significant differences between PCT in specific groups of pathogens (P0.001), with the highest concentrations of Ecoli, streptococcus and other EcoliPCT has the highest rate of urinary tract infections, followed by abdominal infections and the lowest in respiratory tract infections (p.001)In the linear regression model, streptococcus, Ecoli and other Ecoli strains detected in BC were associated with more than three times the PCT valueUrinary genital or abdominal infections were associated with a 2-fold increase in PCT values, not pathogens, the results show that the serum PCT concentration in patients with Gram-negative mystiemia patients is higher than in patients with Gram-positive mystiemia or CandidaHowever, the differential ness of this difference is too low to guide treatment decisionsDifferences in PCT serum concentrations are not entirely determined by Gram-negative or Gram-positive bacteria, but are also affected by different groups of pathogens and different infection strains