【CSCO 2022 Preview】Metaverse positioning technology combined with photodynamic targeted comprehensive treatment of glioma

Glioma refers to tumors originating from brain glial cells, is the most common primary intracranial tumor, the 2021 edition of WHO central nervous system tumor classification will divide brain glioma into grade 1~4, grade 1, 2 for low-grade glioma, grade 3, 4 for high-grade glioma
.
The annual incidence of glioma in China is 5~8/100,000, and the 5-year mortality rate is second only to pancreatic cancer and lung cancer
in systemic tumors.

Photodynamic therapy (PDT) refers to the energy level transition after the photosensitizer absorbs light energy under the irradiation of a specific wavelength of light, and the electrons produced combine with the surrounding oxygen to generate ROS of reactive oxygen species (such as · OH, 1O2, superoxide anion, etc.
), oxidizing biological macromolecules such as lipids, proteins and DNA in cells, thereby inducing bacterial or tumor cell death
.
Among them, photosensitizers, as the core materials of PDT, determine their use conditions and therapeutic efficiency, and the most commonly used photosensitizers include porphyrins, phthalocyanines and their derivatives
.

Gliomas are deep tumors and are quite difficult
in the field of photodynamic therapy.
First, to test the doctor's surgical treatment skills, precision resection technology for the operation of the doctor under the microscope is very high, second, many gliomas are involved in the functional area, how to maximize the removal of the tumor and protect the function, this is a great challenge, which also limits the clinical application
of tumor photodynamic therapy.
If the surgical resection is not good, the effect of photodynamic therapy is not good
.
Only precise excision, combined with photodynamic targeting of the "germinal interface", will have a better treatment effect
.

How to achieve the precise positioning of photodynamic therapy? The hot metaverse may provide us with new ideas
.
What is the metaverse? From the perspective of the English name, Metaverse = Meta (transcendence) + universe (universe), which is a virtual space built by information technology parallel to and independent of the real world, is a digital virtual world that reflects the real world, and is the "transcendence"
of the real world 。 The immersion and expansion of the metaverse are inseparable from VR, AR, MR and other display and interaction technologies, according to a random survey conducted by the University of California, Los Angeles, the use of VR technology for surgical training, compared with traditional teaching, the speed of surgical completion is 20%, and the degree of surgical completion is 38%
higher.

On July 11, 2022, the team of Professor Hu Shaoshan, Department of Neurosurgery, Zhejiang Provincial People's Hospital, used meta-universe positioning technology to carry out photodynamic targeted therapy on patients with glioma of one brain, realizing precise resection of tumors, and the operation process was smooth, and the patients were discharged from the hospital 10 days after surgery and entered the follow-up stage
.
This classic case provides us with a realistic template
for imagining the combination of metaverse and medical technology.

On November 9, 2022, the 25th National Congress of Clinical Oncology and the 2022 CSCO Annual Conference specially invited Professor Hu Shaoshan to introduce the application of metaverse technology to promote the precision treatment of tumors, and look forward to bringing us more surprises
from this cutting-edge new technology.

Resources:

https://mp.
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https://mp.
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https://mp.
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com/s/zGpqJ-fOrBFvyTNVJk6Zxg

https://mp.
weixin.
qq.
com/s/2lIATqskQTTCkfeDqSPrmA

https://mp.
weixin.
qq.
com/s/DnYz-PHIWv8JDgA1B8zl8Q