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    Home > Active Ingredient News > Immunology News > CTD Journal Inhaled ibuprofen salts have potential to reverse pulmonary vascular paralysis in patients with COVID-19 pneumonia

    CTD Journal Inhaled ibuprofen salts have potential to reverse pulmonary vascular paralysis in patients with COVID-19 pneumonia

    • Last Update: 2022-06-05
    • Source: Internet
    • Author: User
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    Recent studies have shown that an inhaled, non-hormonal anti-inflammatory drug, sodium ibuprofen (NaIHS) dissolved in hypertonic sodium salts, can relieve hypoxia symptoms in patients with moderate to severe COVID-19 pneumonia
    .

    However, the relevant molecular mechanism is still unclear
    .

    The authors hypothesized that the effect of NaIHS is related to indirect inhibition of high production of nitric oxide (NO) in the body
    .

    When a patient with COVID-19 presents with symptoms of vasoplegia, we call it COVID-19 L type
    .

    70-80% of COVID-19 patients are COVID-19 L type
    .

    Of the 383 COVID-19 patients enrolled, 15% had been treated with mechanical ventilation
    .

    Regardless of race, and whether it is a mechanical ventilation group or a non-mechanical ventilation group of COVID-19 patients, after correcting the respiratory rate, the patient's hypoxemia will be effectively reversed, the hospital stay will be shortened, and the mortality rate will be reduced.
    decreased, which was associated with a reduction in the half-life of gaseous NO (usually 1-5 seconds) by the treatment
    .

    When NO harms the human body, its concentration is at the micromolar level and is concentration-dependent
    .


    On January 23, 2022, the journal Clinical and Translational Discovery published online the latest achievement "Potential reversal of pulmonary vasoplegia by inhaled ibuprofenate in COVID-19 pneumonia" from the team of Professor Christian Carlos Zurita-Lizza in Argentina[6] ( 
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