[curative effect] Qitong ® lipoic acid tablet in the treatment of diabetic peripheral neuropathy

With the development of modern medicine, the application of lipoic acid is expanding Many medical researches have shown that Qitong ® lipoic acid tablet produced by Shandong Qidu Pharmaceutical Co., Ltd has not only remarkable curative effect in the treatment of nerve injury, cataract, liver disease, Alzheimer's disease and other diseases, but also can treat diabetic peripheral neuropathy from the "root" and has good therapeutic effect Lipoic acid: the universal super antioxidant lipoic acid is a kind of coenzyme existing in mitochondria, similar to vitamin, which has the function of eliminating the free radicals that accelerate aging and cause disease According to the data, the antioxidant capacity of lipoic acid is 400 times that of vitamin C and 60 times that of vitamin E After lipoic acid is absorbed into cells through intestinal tract, it can reach any cell site because of its dual characteristics of fat solubility and water solubility, so it is also called "universal powerful antioxidant" in medical field In 1980, Professor Sachs of Germany first used lipoic acid to treat diabetic peripheral neuropathy and proved its effectiveness A series of studies conducted in the following 20 years further confirmed this view In Sydney Ⅱ study, 181 patients with type 1 or type 2 diabetes mellitus with definite neurological symptoms were randomly divided into two groups They were given placebo and different doses of oral lipoic acid for 5 weeks The results showed that oral lipoic acid for 5 weeks could effectively improve the symptoms and nerve damage of diabetic peripheral neuropathy, and there was no correlation between the overall effect and dose However, high dose will increase gastrointestinal side effects, so the treatment dose of 600 mg per day has the best risk-benefit ratio In the Nathan 1 study, 460 patients with type 1 or type 2 diabetes mellitus and peripheral neuropathy were randomly divided into two groups They were given placebo and 600 mg / day of oral lipoic acid for 4 years The results showed that compared with placebo, oral lipoic acid treatment can improve and delay neuropathy injury, and has good tolerance All the above studies showed that lipoic acid can effectively improve the symptoms and nerve damage of diabetic peripheral neuropathy According to the Chinese guidelines for the prevention and treatment of type 2 diabetes mellitus (2013 Edition), the treatment of diabetic peripheral neuropathy (DPN) can be divided into two types: treatment for causes and treatment for symptoms Among them, the treatment includes blood glucose control, nerve repair, antioxidant stress, improvement of microcirculation and metabolic disorders In the treatment of oxidative stress, it is mentioned that "oxidative stress is the tissue damage caused by excessive or reduced scavenging of highly active molecules such as reactive oxygen species produced by the body under the action of high glucose, hypoxia ischemia and other damage factors." As the only recommended common drug for anti oxidative stress treatment, Shandong Qidu pharmaceutical Qitong ® lipoic acid tablet can effectively treat diabetic peripheral neuropathy by inhibiting lipid peroxidation, increasing blood flow of neurotrophic vessels, increasing Na + - K + - ATPase activity and protecting endothelial function Compared with the nerve repair drug Mecobalamin, Qitong ® lipoic acid tablet is more effective The improvement effect of motor nerve conduction velocity, sensory nerve conduction velocity and ankle brachial index is better, the time of relief is shorter, the time of onset is faster, and the incidence of adverse reactions is lower Qitong ® lipoic acid tablet has good curative effect and is convenient to take at the same time After lipoic acid injection treatment, it can be taken orally in sequence to achieve a complete course of treatment, so that patients can obtain satisfactory curative effect With its excellent efficacy and treatment compliance, Qitong ® lipoic acid tablet is bound to open up a broad market in China