Curcumin may help improve exercise intolerance in patients with chronic heart failure

Curcumin may help improve exercise intolerance in patients with chronic heart failure, according to a new study published in the Journal of Applied Physiology Based on the results of this study and previous research evidence, the researchers pointed out that more targeted drugs should be developed (http:// and patients should be encouraged to eat foods rich in nuclear factor E2 related factor 2 (Nrf2) activators Because the activation of Nrf2 in skeletal muscle may mean a new treatment, which can improve the quality of life in patients with heart failure with reduced ejection fraction Previous studies have shown that a decrease in Nrf2, a protein that regulates the expression of antioxidant enzymes, may lead to a decrease in exercise capacity, while curcumin can promote the activation of Nrf2 protein molecules Based on this, the researchers attempted to explore the effect of curcumin on heart failure mice that reduce ejection fraction The researchers administered curcumin to one group of mice with heart failure for 12 weeks, but not to the other group of mice with heart failure; two other groups were healthy (http:// Mice were treated with curcumin in the same way After the experiment, the heart failure group was compared with the healthy mice receiving curcumin and the healthy mice not receiving curcumin (http:// The results showed that the mice treated with curcumin, whether healthy or heart failure, had significantly improved the ability of exercise compared with the two groups not treated, which indicated that the effect of curcumin on skeletal muscle might not be limited to the health benefits of heart failure The researchers further found that higher than normal levels of oxidative stress, two different types of molecular imbalance can lead to cell damage, leading to exercise intolerance in patients with heart failure