Curr Biol: Still staying up late? Sleep patterns may help predict 'dementia' and are more likely to 'get silly' if you don't sleep well, new study finds

Alzheimer's disease (AD) is a neurological degenerative disease with hidden development, and abnormal apogenescies of beta amyloid (A beta) with age are considered to be a major pathological cause of the disease.
, the disease occurs in people over 60 years of age and there is currently no prevention or treatment.
However, a recent study published in Current Biology by researchers in psychology and neuroscience at the University of California, Berkeley, found that "good sleep" may be an important way to deal with Alzheimer's disease today, and that poor sleep quality is consistent with an increase in toxic protein accumulation.
the brain accumulates A-beta faster in people with poorer sleep quality, which indicates a higher risk of Alzheimer's disease.
Matthew P. Walker, senior author of the report and a professor of psychology and neuroscience at the University of California, Berkeley, said: "People now sleep almost like a crystal ball, telling you when and how fast AD develops in your brain.
because the brain flushes itself during deep sleep, it is possible to reverse the flow of time by getting more sleep in the early stages of life.
" In the past, researchers tended to believe that people's sleep problems were a well-known symptom of Alzheimer's disease, but some studies suggest that poor sleep may not be just a consequence of neurodegenerative changes associated with the disease, but may be a potential cause.
animal and human trials have shown that just one night's sleep disruption can increase the accumulation of A-beta, while deep sleep helps people clean up these toxic proteins.
So, in this study, researchers recruited 32 healthy seniors to assess their sleep status and quality using EEG and polysexual sleep maps (PSGs), the former of which demonstrated peak specificity to beta-amyloid protein, and the latter, which is often used to diagnose sleep apnea.
the average age of these participants was 75.5 to 4.3 years, of which 23 were women. Overall, the
participants were followed for an average time of 3.7 years, during which time the researchers regularly tracked the growth rate of A-beta in the participants' brains using a positive electron emission fault scan (PET), compared their A-beta levels with their sleep, and used a linear hybrid effect model to derive the rate of change in the A-beta load of each subject over time.
longitudinal trajectories of beta amyloid plaque deposition are divided into rapid eye movement (REM) sleep and non-rapid eye movement (NREM) sleep, the former also known as fast wave sleep, the latter can be called slow wave sleep.
previous studies have shown that sleep efficiency (total sleep as a percentage of total bedtime) and 0.6-1Hz slow-wave sleep activity (SWA) frequency ratios are associated with changes in beta A.
Then, in further experiments, the researchers first verified the binary correlation intensity between the A-beta rate measurement and the EEG spectral power, and found that the SWA frequency of 0.6-1-Hz was negatively related to the change of beta amyloid protein, while the power of frequency greater than 1Hz was positively related.
, the researchers examined the relationship between sleep efficiency and changes in A-beta and found that participants who initially experienced more fragmented sleep and less NREM slow-wave sleep were most likely to exhibit an increase in A-beta during the study.
and although all participants remained healthy throughout the study period, the annual changes in A-beta in subjects with higher and lower sleep efficiency were found to be associated with the quality of sleep at baseline.
, that is, getting good and adequate sleep early will help prevent Alzheimer's disease in the future.
"We can assess how sleep quality predicts changes in beta amyloid plaques at multiple points in time, rather than waiting years for patients to develop dementia," said Lead author Joseph Winer of the report on regional differences in annual longitudinal accumulation patterns of beta amyloid based on baseline sleep measurements.
, we can measure how quickly this toxic protein accumulates in the brain over time.
, "It would be a significant and promising step forward if we could reduce the risk of Alzheimer's by improving sleep," Walker said.
, the study suggests that sleep assessment may provide a non-invasive alternative to help predicting the deposition of beta-amyloid plaques in the brain.
, researchers are exploring ways to get people at high risk of Alzheimer's to sleep and implement methods that could improve sleep quality.
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