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Mutations related to therapeutic resistance mechanisms (IRB Barcelona)
It is estimated that 80% of women will suffer from vaginal candidiasis at least once in their lifetime
.
In addition to superficial infections (which can be oral or vaginal infections, and the prognosis is usually not serious), Candida fungi can cause systemic diseases in immunocompromised individuals.
These diseases are fatal in 40% of cases
Scientists led by Dr.
Toni Gabaldón, a researcher at ICREA, head of the Institute of Biomedical Research (IRB Barcelona) and Barcelona Supercomputing Center (BSC), studied the resistance mechanism of Candida glabrata after exposure to various drugs , And identified 8 genes.
Once these genes are mutated, they are responsible for allowing the fungus to adapt and survive the treatment
.
So far, only half of these genes have been considered candidate genes for drug resistance
"The interesting thing about this work is that the identification of these eight genes allows us to use genetic testing to diagnose potential drug resistance in specific patient infections, thereby helping to choose the best treatment," IRB Barcelona Comparative Genomics Laboratory The person in charge, Dr.
Gabaldón, said
.
The evolutionary process of resistance mechanism integration
To conduct this study, the researchers cultivated independent populations of Candida glabrata and treated them with a variety of drugs with different mechanisms of action on the market
.
Then, they analyzed the resulting resistance and the genomes of different groups, linking the mechanism with genetic differences
The strain produced in this work combines resistance to several drugs and can be used as a research model for finding new therapies
.
Resistance transfer phenomenon
In addition to developing resistance to the given treatment, researchers have also observed that in 50% of cases, exposure to a specific drug (fluconazole) also leads to resistance to another drug (macroconazole) Drug properties, although these people have never been exposed to the second drug
.
Dr.
Gabaldón said: "This phenomenon is called cross-resistance.
In this regard, our findings should lead to adjustments to treatment guidelines to avoid the emergence of multi-drug resistance
.
"
Original search:
Narrow mutational signatures drive acquisition of multidrug resistance in the fungal pathogen Candida glabrata
