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    Home > Biochemistry News > Biotechnology News > Cysteinyl leukotriene and IL-25 produced by clustered cells synergistically initiate lung type 2 inflammation

    Cysteinyl leukotriene and IL-25 produced by clustered cells synergistically initiate lung type 2 inflammation

    • Last Update: 2022-01-10
    • Source: Internet
    • Author: User
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    Lung inflammation

    Airway villi cells are sensory cells that cause allergenic lung inflammation
    .
    These clustered cells produce IL-25 and cysteine ​​leukotrienes (CysLTs), but the specific contribution of each mediator to lung inflammation is unclear
    .
    Here you are, YulievaWait a minute
    .
    The airway inflammation in mice induced by slts-25 and slts-2 alone was not obvious
    .
    This inflammation is mainly throughLtc4s company, An enzyme that needs to produce CysLT on clustered cells
    .
    Taken together, these data show the role of CysLT and IL-25 in the airway allergic immune response
    .

    Summary

    The sensitivity of airway epithelial cells to pneumatic allergens triggers a pathogenic immune response, leading to type 2 inflammation, which is a sign of chronic airway diseases such as asthma
    .
    Cluster cells are rare epithelial cells and are the main source of the epithelial cytokine interleukin-25 (IL-25) and the lipid mediator of vascular permeability and chemotaxis-cysteine ​​leukotrienes (CysLTs)
    .
    How these two mediators from the same cell work together to promote type 2 airway inflammation has not yet been elucidated
    .
    Here, we found that the parent leukotriene C is inhaled4(LTC)4) Combined use with a subthreshold dose of IL-25 can activate two types of innate immune cells: inflammatory type 2 innate lymphocytes (ILC2) and dendritic cells (dc) for proliferation and cytokine production
    .
    This synergistic effect leads to a massive recruitment of eosinophils and CD4+T cell expansion shows a synergistic effect
    .
    The increase in pulmonary eosinophils is mainly mediated by the classic CysLT receptor1The activation of R, type 2 cytokines and innate immune cells requires signaling through CysLT1R and part of CysLT2R, clustered cells-specific deletionsLtc4s company, To produce the end enzymes required by CysLT, reduce lung inflammation and systemic immune response after inhalation of mold gas allergensAlternaria;At the same time blocking IL-25 further enhances this effect
    .
    Our findings confirm that the effective synergy of cyslt and IL-25 downstream of the air allergen triggers the activation of airway cluster cells, resulting in a highly polarized type 2 immune response, and further indicates that the airway cluster cells are lung type 2 A powerful regulator of immunity
    .

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