Dai Jianwu's group developed a new type of bifunctional hydrogel scaffold to regulate the immune and inflammatory microenvironment of spinal cord injury, and promote nerve regeneration and functional recovery

Spinal cord injury causes destruction of axons and death of neurons, ultimately leading to dysfunction

The existing control of microenvironment after spinal cord injury mostly adopts a single strategy, and the effect of regeneration and repair is limited

Figure 1 : Schematic diagram of a dual-functional hydrogel scaffold that regulates the immune-inflammatory microenvironment of spinal cord injury 

Studies have shown that photo-crosslinked gelatin hydrogel modified with cationic polymer polyethylenediamine and cytokine can effectively remove DAMP and continuously release IL-10 , reducing the M1 polarization and pro-inflammatory cells of macrophages and microglia Factor secretion, antagonizes DAMPs and inhibits neural stem cell differentiation into nerves

Work related to " A DAMP-scavenging, IL-10-Releasing hydrogel promotes Neural Regeneration and Motor Recovery function the After spinal Cord injury ," the title, was recently published in the "biological material" ( Biomaterials on)

Figure 2 : Dual-function immuno-inflammation regulating hydrogel ( Scav/Delv-GL ) enhances nerve regeneration and promotes functional recovery