Dalian Institute of Chemical Technology and others have developed a new method for detecting tyrosine phosphorylation based on biomimetic ion channels

Recently, Qing Guangyan, researcher of the Special Zone Research Group of Bioseparation and Interface Molecular Mechanism Innovation, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, and Liang Xinmiao, researcher of the Research Center of Traditional Chinese Medicine, have made new progress in protein phosphorylation and developed a smart polymer function The modified bionic ion channel device realizes the real-time sensing and measurement of tyrosine phosphorylation, and shows good application potential in the screening of tyrosine kinase inhibitors

Protein tyrosine phosphorylation is a key regulation mechanism of cell activity, and abnormal tyrosine phosphorylation is closely related to the occurrence of a variety of cancers

The team designed a smart polymer containing polyguanidine groups by mimicking the interaction between arginine and tyrosine phosphate residues in proteins, and modified them into tapered nanopores to prepare a functional ion channel Device

Relevant results were published in "Journal of the American Chemical Society" (J.

Dalian Institute of Chemical Technology has developed a new method for detecting tyrosine phosphorylation based on biomimetic ion channels