Data from 130,000 people in Shanghai, a sub-journal of BMJ, show that the diversity of the oral microbiome is associated with the risk of lung cancer in non-smokers

After the completion of the Human Genome Project, the National Institutes of Health (NIH) launched the Human Microbiome Project (HMP) for the Second Genome in late 2007 to analyze the effects of changes in the microbiome on human health by mapping the microbiome genome structure of five parts of the human body (oral, nasal, vaginal, intestinal, skin).
the Human Microbiome program has set off a global microbiome research boom.
, as one of the important components of the human microbiome, the oral microbiome has become the focus of HMP and the "National Individual Microbiome Detection Project" because of its convenient material and close relationship with oral and general health.
the oral microbiome is a collection of microorganisms designated in the human oral cavity, mostly in the form of biofilms to exercise microbial physiology functions.
When the ecological relationship between the microbiome and the host is unbalanced, it can induce a variety of oral infectious diseases, including rickets, myeloid periodont disease, periodontage disease, wisdom tooth coronary inflammation, maxillomoartitis, etc., which seriously endanger oral health.
More importantly, the oral microbiome is closely related to systemic diseases such as oral tumors, diabetes, rheumatoid arthritis, cardiovascular disease and premature birth, and the structural characteristics of the oral microbiome can be used as an important marker for early warning of oral and general health.
to explore whether oral microbiome diversity is associated with the risk of lung cancer in non-smokers, a team of scientists from Vanderbilt University in the United States, the National Cancer Institute, and the Shanghai Cancer Institute in China conducted forward-looking studies.
results were published in the latest BMJ sub-issue, Thorax.
The study selected two prospective nest case control studies, the Shanghai Women's Health Study (SWHS, n=74941) and the Shanghai Men's Health Study (SMHS, n=61480), all of which were non-smokers and had no cancer at baseline.
study, 114 participants (90 women and 24 men) developed lung cancer, with a medium diagnosis of 7.2 years.
Then, the researchers selected 114 control groups that matched the sex, age (≤2 years), sample collection date (≤30 days) and time (morning/afternoon), antibiotic use (yes/no) and menouse (female) 1:1 in the week before sample collection.
the structure and abundance of the microbiome in each pathology and control group pre-diagnosis oral flushing sample using source genomic sequencing.
use multivariate logic regression models to estimate the α risk of lung cancer and the relative abundance of clusters.
based on the Microbial Regression Kernel Association Test (MiRKAT) assessed the link between risk and β diversity of the microbiome.
showed that subjects with α microbial α diversity had an increased risk of lung cancer compared to subjects with higher microbial diversity, while β diversity showed no significant case-control differences.
multiple comparisons, spirochaetia (OR=0.42) and Alteroides (OR=0.31) were found to reduce the risk of lung cancer, while increased abundance of Bacilli (OR=1.49) and Lacbactoillales (OR=2.15) significantly increased the risk of lung cancer.
the above results provide an important basis for us to further understand the causes of non-smoking lung cancer patients.
suggest that future studies will focus on the abundance of certain oral microbiomes and the mechanisms for changes in lung cancer risk.
: Hosgood HD, et al. Variation in oral microbiome is associated with future risk of lung cancer among never-smokers. Thorax. 2020 Dec 14:thoraxjnl-2020-215542. doi: 10.1136/thoraxjnl-2020-215542. MedSci Original Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that indicate "Source: Mets Medicine" or "Source: MedSci Original" are owned by Mets Medicine and are not authorized to be reproduced by any media, website or individual, and are authorized to be reproduced with the words "Source: Mets Medicine".
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